Current state and future directions of genomic medicine in aortic dissection: A path to prevention and personalized care.
Journal
Seminars in vascular surgery
ISSN: 1558-4518
Titre abrégé: Semin Vasc Surg
Pays: United States
ID NLM: 8809602
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
23
12
2021
revised:
09
02
2022
accepted:
10
02
2022
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
6
5
2022
Statut:
ppublish
Résumé
Aortic dissection confers high mortality and morbidity rates despite advances in treatment, impacts quality of life, and contributes immense burden to the healthcare system globally. Efforts to prevent aortic dissection through screening and management of modifiable risk factors and early detection of aneurysms should incorporate genomic information, as it is integral to stratifying risk. However, effective integration of genomic-guided risk assessment into clinical practice will require addressing implementation barriers that currently permeate our healthcare systems. The Aortic Dissection Collaborative was established to define aortic dissection research priorities through patient engagement. Using a collaborative patient-centered feedback model, our Genomic Medicine Working Group identified related research priorities that could be investigated by pragmatic interventional studies aimed at aortic dissection prevention, utilization of genomic information to improve patient outcomes, and access to genomic medicine services. Further research is also needed to identify the genomic, lifestyle, and environmental risk factors that contribute to aortic dissection so these data can be incorporated into future comparative effectiveness studies to prevent aortic dissection.
Identifiants
pubmed: 35501041
pii: S0895-7967(22)00006-0
doi: 10.1053/j.semvascsurg.2022.02.003
pmc: PMC9258522
mid: NIHMS1807359
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-59Subventions
Organisme : CSRD VA
ID : IK2 CX001780
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL109942
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
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