Protein kinase Cλ/ι in cancer: a contextual balance of time and signals.

Humans Isoenzymes / metabolism Protein Kinase C / genetics Signal Transduction / physiology Neoplasms / genetics Cell Transformation, Neoplastic / pathology Tumor Microenvironment
autophagy cancer interferon metabolism protein kinase C tumor microenvironment

Journal

Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566

Informations de publication

Date de publication:
12 2022
Historique:
received: 24 02 2022
revised: 01 04 2022
accepted: 04 04 2022
pubmed: 3 5 2022
medline: 16 11 2022
entrez: 2 5 2022
Statut: ppublish

Résumé

Nononcogenic cancer drivers often impinge on complex signals that create new addictions and vulnerabilities. Protein kinase Cλ/ι (PKCλ/ι) suppresses tumorigenesis by blocking metabolic pathways that regulate fuel oxidation and create building blocks for the epigenetic control of cell differentiation. Reduced levels of PKCλ/ι unleash these pathways to promote tumorigenesis, but the simultaneous activation of the STING-driven interferon cascade prevents tumor initiation by triggering immunosurveillance mechanisms. However, depending on the context of other signaling pathways, such as WNT/β-catenin or PKCζ, and timing, PKCλ/ι deletion can promote or inhibit tumorigenesis. In this review, we discuss in detail the molecular and cellular underpinnings of PKCλ/ι functions in cancer with the perspective of the crosstalk between metabolism and inflammation in the tumor microenvironment.

Identifiants

DOI: 10.1016/j.tcb.2022.04.002 PMID: 35501226 PMC: PMC9716658
pubmed: 35501226
pii: S0962-8924(22)00090-3
doi: 10.1016/j.tcb.2022.04.002
pmc: PMC9716658
mid: NIHMS1846773
pii:
doi:

Substances chimiques

Isoenzymes 0
Protein Kinase C EC 2.7.11.13

Types de publication

Journal Article Review Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1023-1034

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK108743
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA265892
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211794
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA207177
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA246765
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA250025
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218254
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests J.M. and M.T.D-M are co-founders, shareholders, and members of the board of ZelamBio Inc. The other authors have no interests to declare.

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Auteurs

Jorge Moscat (J)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address: jom4010@med.cornell.edu.

Juan F Linares (JF)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.

Angeles Duran (A)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.

Maria T Diaz-Meco (MT)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address: mtd4001@med.cornell.edu.

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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Isoenzymes › Protein kinase Cλ/ι in cancer: a contextual...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Protéine kinase C › Protein kinase Cλ/ι in cancer: a contextual...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Protein kinase Cλ/ι in cancer: a contextual...
questionsmedicales.fr › Tumeurs › Protein kinase Cλ/ι in cancer: a contextual...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › Protein kinase Cλ/ι in cancer: a contextual...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Protein kinase Cλ/ι in cancer: a contextual...