Role of cathepsin K in the expression of mechanical hypersensitivity following intra-plantar inflammation.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 05 2022
02 05 2022
Historique:
received:
18
11
2021
accepted:
14
04
2022
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
6
5
2022
Statut:
epublish
Résumé
Persistent/chronic inflammatory pain involves multiple pathophysiological mechanisms and is far more complex than acute/momentary pain. Current therapeutics for chronic inflammatory pain are often not effective because the etiology responsible for the pain is not addressed by traditional pharmacological treatments. Cathepsin K is a cysteine protease that has mostly been studied in the context of bone and joint disorders. Previous work by others has shown that inhibition of cathepsin K activity reduces osteoarthritis-associated nociception in joints. However, the role of cathepsin K in cutaneous inflammation is understudied. We assessed the effectiveness of genetic deletion or pharmacological inhibition of cathepsin K in male mice on the expression of nocifensive behaviors after formalin injection or mechanical and thermal hypersensitivity after injection of complete Freund's adjuvant (CFA) into the mouse hind paw. Our data demonstrate that cathepsin K knockout mice (Ctsk
Identifiants
pubmed: 35501334
doi: 10.1038/s41598-022-11043-9
pii: 10.1038/s41598-022-11043-9
pmc: PMC9061763
doi:
Substances chimiques
Freund's Adjuvant
9007-81-2
Cathepsin K
EC 3.4.22.38
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
7108Subventions
Organisme : NIH HHS
ID : P30 GM 103398-32128
Pays : United States
Informations de copyright
© 2022. The Author(s).
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