Effect of Sex on Structural and Morphological Parameters of Rat Heart under Conditions of Combined Exposure to Hypokinesia and Cold.
WKY and SHR rats
combined effects of hypokinesia and cold
heart morphology
males and females
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
01
10
2021
pubmed:
3
5
2022
medline:
20
5
2022
entrez:
2
5
2022
Statut:
ppublish
Résumé
We studied the combined effect of hypokinesia and external cooling on structural and morphological changes in the ventricular myocardium and parameters of homeostasis of the blood system in male and female WKY (normotensive) and SHR (hypertensive) rats. Simultaneous exposure to hypokinesia and cold caused destructive processes in the myocardium and high dynamics of heart remodeling with diverse structural and morphological changes in the left ventricle in rats of both sexes. The thickness of the left ventricular wall most rapidly decreased in male hypertensive SHR rats. The thickness of the wall of the right ventricle significantly increased in male and female rats of both strains. In WKY and SHR females, structural transformations in the heart were less pronounced than in males. The key role in different degree of morphological remodeling of the myocardium in male and female probably belongs to sex hormones.
Identifiants
pubmed: 35501654
doi: 10.1007/s10517-022-05476-5
pii: 10.1007/s10517-022-05476-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
775-778Informations de copyright
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.
Références
Belovol AN, Knyaz’kova II, Tsygankov AI. Gender characteristics of the renin-angiotensin-aldosterone system: clinical significance in arterial hypertension. Gendernaya Medistina. 2014;(3-4):18-24. Russian.
Lakomkin VL, Konovalova GG, Kalenikova EI, Zabbarova IV, Tsyplenkova VG, Tikhase AK, Lankin VZ, Ruuge EK, Kapelko VI. Effect of ubiquinone on contractile function and antioxidant status of the myocardium in spontaneously hypertensive rats. Kardiologiya. 2006;46(5):54-62. Russian.
pubmed: 16858356
Nadeev AD, Goncharov NV. Reactive oxygen species in the cells of cardiovascular system . Kopmleks. Probl. Serd.-Sosud. Zabolev. 2014;(4):80-94. Russian.
Osadchuk LV, Gutorova NV, Ludinina AYu, Potolitsyna NN, Bojko ER. Changes in hormonal and metabolic status in men of an ethnic group komi with overweight and obesity. Ozhirenie Metabolizm. 2013;10(2):28-32. Russian.
Panin LE. Fundamental problems of the circumpolar and the Arctic medicine. Byull. Sib. Otdel. Ross. Akad. med. Nauk. 2013;33(6):5-10. Russian.
Folkow B. Mental stress and its importance for cardiovascular disorders. Kardiologiya. 2007;47(10):4-11. Russian.
pubmed: 18260938
Hasnulin VI, Voevoda MI, Hasnulin PV, Artamonova OG. Modern approach to arterial hypertension in the circumpolar and arctic regions. Literature review. Ekol. Chel. 2016;(3):43-51. Russian.
Hasnulin VI, Gafarov VV, Voevoda MI, Artamonova MV. Mortality from diseases of the cardiovascular system based on the average air temperature and residence geographical latitudes in Russia. Mezhdunarod. Zh. Priklad. Fundament. Issled. 2015;(6-2):255-259. Russian.
Shemarova IV, Nesterov VP. Evolution of mechanisms of Ca
doi: 10.1134/S0022093013010027
Shmakov DN, Nuzhny VP, Kibler NA. Combined Effects of Hypokinesia and Ambient Temperature on Heart Remodeling in Normotensive and Hypertensive Rats. Bull. Exp. Biol. Med. 2019;167(6):720-722. doi: https://doi.org/10.1007/s10517-019-04607-9
doi: 10.1007/s10517-019-04607-9
pubmed: 31655994
Shmakov DN, Nuzhny VP, Kibler NA, Kharin SN. Changes in Total Cholesterol and Heart Rate in Normotensive and Hypertensive Rats under Combined Influence of Cold Exposure and Hypokinesia. Bull. Exp. Biol. Med. 2020;169(6):738-741. doi: https://doi.org/10.1007/s10517-020-04968-6
doi: 10.1007/s10517-020-04968-6
pubmed: 33123917
EUGenMed Cardiovascular Clinical Study Group, Regitz-Zagrosek V, Oertelt-Prigione S, Prescott E, Franconi F, Gerdts E, Foryst-Ludwig A, Maas A.H, Kautzky-Willer A, Knappe-Wegner D, Kintscher U, Ladwig KH, Schenck-Gustafsson K, Stangl V. Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes. Eur. Heart J. 2016;37(1):24-34. doi: https://doi.org/10.1093/eurheartj/ehv598
Galiuto L, Locorotondo G. Gender differences in cardiovascular disease. J. Integr. Cardiol. 2015;1(1):20-22. doi: 10.15761/JIC.1000107
Lee SK. Sex as an important biological variable in biomedical research. BMB Rep. 2018;51(4):167-173. doi: https://doi.org/10.5483/bmbrep.2018.51.4.034
doi: 10.5483/bmbrep.2018.51.4.034
pubmed: 29429452
pmcid: 5933211
Mauvais-Jarvis F, Bairey Merz N, Barnes PJ, Brinton RD, Carrero JJ, DeMeo DL, De Vries GJ, Epperson CN, Govindan R, Klein SL, Lonardo A, Maki PM, McCullough LD, Regitz-Zagrosek V, Regensteiner JG, Rubin JB, Sandberg K, Suzuki A. Sex and gender: modifiers of health, disease, and medicine. Lancet. 2020;396:565-582. doi: https://doi.org/10.1016/S0140-6736(20)31561-0
doi: 10.1016/S0140-6736(20)31561-0
pubmed: 32828189
pmcid: 7440877