The accumulation of Vγ4 T cells with aging is associated with an increased adaptive Vγ4 T cell response after foodborne Listeria monocytogenes infection of mice.
Foodborne infection
Immunosenescence
Listeria monocytogenes
Mucosal immunity
γδ T cells
Journal
Immunity & ageing : I & A
ISSN: 1742-4933
Titre abrégé: Immun Ageing
Pays: England
ID NLM: 101235427
Informations de publication
Date de publication:
03 May 2022
03 May 2022
Historique:
received:
23
12
2021
accepted:
19
04
2022
entrez:
3
5
2022
pubmed:
4
5
2022
medline:
4
5
2022
Statut:
epublish
Résumé
It is generally accepted that aging has detrimental effects on conventional T cell responses to systemic infections. However, most pathogens naturally invade the body through mucosal barriers. Although mucosal sites are highly enriched in unconventional immune sentinels like γδ T cells, little is currently known about the impact of aging on unconventional mucosal T cell responses. We previously established that foodborne infection with a mouse-adapted internalin A mutant Listeria monocytogenes (Lm) generates an adaptive intestinal memory CD44 Foodborne Lm infection of female Balb/c and C57BL/6 mice led to an increased adaptive CD44 Lm-elicited adaptive Vγ4 T cells appear resistant to immunosenescence and memory Vγ4 T cells could be utilized to provide protective immune functions during enteric infection of aged hosts. As such, oral immunization might offer an efficient therapeutic approach to generate unconventional memory T cells in the elderly.
Sections du résumé
BACKGROUND
BACKGROUND
It is generally accepted that aging has detrimental effects on conventional T cell responses to systemic infections. However, most pathogens naturally invade the body through mucosal barriers. Although mucosal sites are highly enriched in unconventional immune sentinels like γδ T cells, little is currently known about the impact of aging on unconventional mucosal T cell responses. We previously established that foodborne infection with a mouse-adapted internalin A mutant Listeria monocytogenes (Lm) generates an adaptive intestinal memory CD44
RESULTS
RESULTS
Foodborne Lm infection of female Balb/c and C57BL/6 mice led to an increased adaptive CD44
CONCLUSIONS
CONCLUSIONS
Lm-elicited adaptive Vγ4 T cells appear resistant to immunosenescence and memory Vγ4 T cells could be utilized to provide protective immune functions during enteric infection of aged hosts. As such, oral immunization might offer an efficient therapeutic approach to generate unconventional memory T cells in the elderly.
Identifiants
pubmed: 35501808
doi: 10.1186/s12979-022-00275-y
pii: 10.1186/s12979-022-00275-y
pmc: PMC9063344
doi:
Types de publication
Journal Article
Langues
eng
Pagination
19Subventions
Organisme : NIH HHS
ID : R21 AI076457
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG058981
Pays : United States
Organisme : NIH HHS
ID : T32 AI007539
Pays : United States
Organisme : NIH HHS
ID : K12 GM102771
Pays : United States
Organisme : G. Harold and Leila Y. Mathers Foundation
ID : MF-1901-00210
Informations de copyright
© 2022. The Author(s).
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