The superficial zone of articular cartilage.
Articular cartilage
Lubricin
Osteoarthritis
Superficial zone
Journal
Inflammation and regeneration
ISSN: 1880-9693
Titre abrégé: Inflamm Regen
Pays: England
ID NLM: 101479577
Informations de publication
Date de publication:
02 May 2022
02 May 2022
Historique:
received:
27
12
2021
accepted:
21
02
2022
entrez:
3
5
2022
pubmed:
4
5
2022
medline:
4
5
2022
Statut:
epublish
Résumé
The superficial zone of articular cartilage contributes to smooth joint motion through the production of proteoglycan 4 (PRG4), also known as lubricin. Recent studies indicate novel effects of PRG4 as a signaling molecule, other than a simple extracellular matrix protein. Additionally, the accumulating evidence displays that various molecules and signaling pathways are involved in regulating the superficial zone and PRG4 expression. In addition, Prg4-expressing cells include a progenitor population of articular chondrocytes. Several non-clinical and clinical studies have shown that PRG4 and related molecules are promising candidates for disease-modifying drugs for treating osteoarthritis. Since PRG4 is also expressed in the synovium, tendons, and ligaments, further studies of PRG4-related pathways and PRG4-positive cells may elucidate the mechanisms underlying joint homeostasis.
Identifiants
pubmed: 35501926
doi: 10.1186/s41232-022-00202-0
pii: 10.1186/s41232-022-00202-0
pmc: PMC9059385
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
14Informations de copyright
© 2022. The Author(s).
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