A Rare Case of Myxochondroid Metaplasia of the Plantar Foot With Review of Histopathological Mimics.
Journal
The American Journal of dermatopathology
ISSN: 1533-0311
Titre abrégé: Am J Dermatopathol
Pays: United States
ID NLM: 7911005
Informations de publication
Date de publication:
01 Oct 2022
01 Oct 2022
Historique:
pubmed:
4
5
2022
medline:
23
9
2022
entrez:
3
5
2022
Statut:
ppublish
Résumé
Chondromyxoid metaplasia can rarely lead to the formation of a distinctive tumor-like proliferation in the plantar foot. This is thought to represent a reactive or reparative process, possibly due to chronic trauma. For the unwary dermatopathologist, this could represent a diagnostic challenge. Herein, we review the clinical, histopathological, and molecular presentation of an athletic 17-year-old boy with a soft tissue mass arising in the right plantar foot. Microscopic examination showed a relatively circumscribed proliferation of spindle cells with abundant chondromyxoid stroma, hyalinization, and diffuse ERG reactivity. We also review characteristics of this entity that help differentiate it from clinical and histopathologic mimics and postulate possible links with soft tissue chondromas and immature chondroid choristoma.
Identifiants
pubmed: 35503890
doi: 10.1097/DAD.0000000000002214
pii: 00000372-202210000-00022
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e113-e116Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Sweeney SP, Royer MC. NRAS mutation detected in a melanoma with chondroid stroma: a case report with molecular evaluation and literature review of a rare form of melanoma. Am J Dermatopathol. 2020;42:608–611.
Gallagher SJ, Bailey T, Rawson RV, et al. Melanoma with osseous or chondroid differentiation: a report of eight cases including SATB2 expression and mutation analysis. Pathology. 2021;53:830–835.
Henning A, Banks M, Korman AM, et al. GATA-3 expression in a de-differentiated chondrosarcoma with cutaneous iatrogenic implantation: a diagnostic pitfall with important clinical implications. J Cutan Pathol. 2021;48:932–936.
Wan H, Xu M, Xia T. Clinical and pathological study on mixed tumors of the skin. Medicine (Baltimore). 2018;97:e12216.
Shon W, Folpe AL. Myxochondroid metaplasia of the plantar foot: a distinctive pseudoneoplastic lesion resembling nuchal fibrocartilaginous pseudotumor and the equine digital cushion. Mod Pathol. 2013;26:1561–1567.
Beaubier N, Tell R, Lau D, et al. Clinical validation of the tempus xT next-generation targeted oncology sequencing assay. Oncotarget. 2019;10:2384–2396.
Laskin WB, Fetsch JF, Miettinen M. Nuchal fibrocartilaginous pseudotumor: a clinicopathologic study of five cases and review of the literature. Mod Pathol. 1999;12:663–668.
Snider MP, Clancy WG, McBeath AA. Plantar fascia release for chronic plantar fasciitis in runners. Am J Sports Med. 1983;11:215–219.
Stevens S, Agten A, Wisanto E, et al. Chondroid metaplasia of paraspinal connective tissue in the degenerative spine. Anat Cel Biol. 2019;52:204–207.
Amary F, Perez-Casanova L, Ye H, et al. Synovial chondromatosis and soft tissue chondroma: extraosseous cartilaginous tumor defined by FN1 gene rearrangement. Mod Pathol. 2019;32:1762–1771.
Whittaker GA, Munteanu SE, Menz HB, et al. Corticosteroid injection for plantar heel pain: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2019;20:378.
Creytens D. ERG expression in chondrogenic bone and soft tissue tumours: importance of antibody clone. Comment on Shon et al (2015). J Clin Pathol. 2015;68:1043.
Shon W, Folpe AL, Fritchie KJ. ERG expression in chondrogenic bone and soft tissue tumours. J Clin Pathol. 2015;68:125–129.
Mohr W, Kuhn C, Pelster B, et al. S-100 protein in normal, osteoarthrotic, and arthritic cartilage. Rheumatol Int. 1985;5:273–277.
Nakamura Y, Becker LE, Marks A, et al. S-100 protein in tumors of cartilage and bone. An immunohistochemical study. Cancer. 1983;52:1820–1824.
Lu H, Chen LF, Chen Q, et al. A rare large cutaneous chondroid syringoma involving a toe: a case report. Medicine (Baltimore). 2018;97:e9825.
Cullen D, Diaz Recuero JL, Cullen R, et al. Superficial acral fibromyxoma: report of 13 cases with new immunohistochemical findings. Am J Dermatopathol. 2017;39:14–22.
Moulonguet I, Goettmann S, Zaraa I. Superficial acral fibromyxoma with cartilaginous metaplasia. Am J Dermatopathol. 2019;41:316–317.
Chung EB, Enzinger FM. Chondroma of soft parts. Cancer. 1978;41:1414–1424.
Benradi L, El Haissoufi K, Haloui A, et al. Soft tissue chondroma of the plantar foot in a 14-year-old boy: a case report. Int J Surg Case Rep. 2022;90:106688.
Hao X, Yim J, Qi C, et al. Soft-tissue chondroma in the right hallux: a case report. J Am Podiatr Med Assoc. 2019;109:451–454.
Hsueh S, Santa Cruz DJ. Cartilaginous lesions of the skin and superficial soft tissue. J Cutan Pathol. 1982;9:405–416.
Berlucchi S, Nasi D, Zunarelli E, et al. Cutaneous metastasis from cervical spinal chordoma: case report and literature review. World Neurosurg. 2020;137:296–303.
Folpe AL, Weiss SW. Ossifying fibromyxoid tumor of soft parts: a clinicopathologic study of 70 cases with emphasis on atypical and malignant variants. Am J Surg Pathol. 2003;27:421–431.
Carter CS, Patel RM. Ossifying fibromyxoid tumor: a review with emphasis on recent molecular advances and differential diagnosis. Arch Pathol Lab Med. 2019;143:1504–1512.
Suster D, Ronen S, Mackinnon AC, et al. Immature chondroid choristoma: clinicopathologic, immunohistochemical, and molecular study of an unusual benign skin tumor. Am J Dermatopathol. 2022;44:148–151.