Nanosilver-stimulated heterophil extracellular traps promoted liver and kidney injury in chicken.
Chicken
Heterophils
Heterophils extracellular traps
Injury
Nanosilver
Journal
Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
25
01
2022
revised:
13
04
2022
accepted:
16
04
2022
pubmed:
4
5
2022
medline:
9
6
2022
entrez:
3
5
2022
Statut:
ppublish
Résumé
Nanosilver is a metallic silver monomer with a diameter of <100 nm, which has excellent antibacterial activity and is widely used in the fields of medicine and sanitation, disinfection of drinking water in daily life and feed additives in livestock and poultry farming. Heterophil extracellular traps (HETs) are an important part of innate immunity in chickens and have an excellent antimicrobial effect, but their excessive release caused tissue damage. Nanosilver overdose caused toxic effects in chickens, while immunotoxic effects of nanosilver on chickens have not been reported. In this study, we explored the effects of nanosilver-induced HETs on chicken liver and kidney damage and further investigated the molecular mechanism of nanosilver-induced HETs release. The results showed that nanosilver significantly upregulated serum HETs and caused liver and kidney damage. The classical structure of nanosilver-induced HETs was also observed, and nanosilver-induced HETs were dependent on reactive oxygen species (ROS), extracellular regulatory protein kinase (ERK)
Identifiants
pubmed: 35504082
pii: S0162-0134(22)00127-1
doi: 10.1016/j.jinorgbio.2022.111838
pii:
doi:
Substances chimiques
Silver
3M4G523W1G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111838Informations de copyright
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