Datinolides E-I, five new withanolides with anti-inflammatory activity from the leaves of Datura inoxia Mill.

Anti-Inflammatory Agents / chemistry Datura / chemistry Molecular Structure Plant Leaves / chemistry Withanolides / chemistry
Anti-inflammatory activities Datura inoxia Mill. Solanaceae Withanolide

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Jun 2022
Historique:
received: 15 02 2022
revised: 24 04 2022
accepted: 27 04 2022
pubmed: 4 5 2022
medline: 20 5 2022
entrez: 3 5 2022
Statut: ppublish

Résumé

Five new withanolides, datinolides E-I (1-5), and three known withanolides (6-8) were separated from Datura inoxia Mill. leaves, and datinolide E (1) was the first withanolide with C-27 connected to a nitrogen-containing group. Their structures were clarified by comprehensive spectroscopic analysis and comparison with literature. The anti-inflammatory of isolated compounds against RAW264.7 cells was investigated by the CCK8 assay.

Identifiants

DOI: 10.1016/j.fitote.2022.105204 PMID: 35504512
pubmed: 35504512
pii: S0367-326X(22)00082-X
doi: 10.1016/j.fitote.2022.105204
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Withanolides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105204

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Auteurs

Jia-Tong Wu (JT)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Yan Liu (Y)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Yi-Kai Jiang (YK)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Si-Yi Wang (SY)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Chen-Yu Jiang (CY)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Adnan Mohammed Algradi (AM)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Juan Pan (J)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Wei Guan (W)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Hai-Xue Kuang (HX)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China. Electronic address: hxkuang@yahoo.com.

Bing-You Yang (BY)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China. Electronic address: ybywater@163.com.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Datinolides E-I, five new withanolides with...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Solanales › Solanaceae › Datura › Datinolides E-I, five new withanolides with...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Datinolides E-I, five new withanolides with...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Feuilles de plante › Datinolides E-I, five new withanolides with...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Phytostérols › Withanolides › Datinolides E-I, five new withanolides with...