Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure.
environmental factors
epigenetics
folic acid
neural tube defect
neurulation
pathogenesis
Journal
WIREs mechanisms of disease
ISSN: 2692-9368
Titre abrégé: WIREs Mech Dis
Pays: United States
ID NLM: 9918227353306676
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
04
04
2022
received:
26
01
2022
accepted:
06
04
2022
pubmed:
4
5
2022
medline:
17
9
2022
entrez:
3
5
2022
Statut:
ppublish
Résumé
Neural tube closure (NTC) is crucial for proper development of the brain and spinal cord and requires precise morphogenesis from a sheet of cells to an intact three-dimensional structure. NTC is dependent on successful regulation of hundreds of genes, a myriad of signaling pathways, concentration gradients, and is influenced by epigenetic and environmental cues. Failure of NTC is termed a neural tube defect (NTD) and is a leading class of congenital defects in the United States and worldwide. Though NTDs are all defined as incomplete closure of the neural tube, the pathogenesis of an NTD determines the type, severity, positioning, and accompanying phenotypes. In this review, we survey pathogenesis of NTDs relating to disruption of cellular processes arising from genetic mutations, altered epigenetic regulation, and environmental influences by micronutrients and maternal condition. This article is categorized under: Congenital Diseases > Genetics/Genomics/Epigenetics Neurological Diseases > Genetics/Genomics/Epigenetics Neurological Diseases > Stem Cells and Development.
Identifiants
pubmed: 35504597
doi: 10.1002/wsbm.1559
pmc: PMC9605354
mid: NIHMS1799087
doi:
Substances chimiques
Folic Acid
935E97BOY8
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1559Subventions
Organisme : NICHD NIH HHS
ID : P01-HD104436
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008759
Pays : United States
Organisme : NICHD NIH HHS
ID : P01 HD104436
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110887
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM142607
Pays : United States
Organisme : NINDS NIH HHS
ID : R01-NS110887
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
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