Perspective of the Induction of Liver Microsomal Cytochrome P450s by Chemical Compounds.

Animals Cytochrome P-450 Enzyme System / metabolism Enzyme Induction Liver / metabolism Mammals / metabolism Microsomes, Liver / metabolism Xenobiotics / pharmacology

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
07 2022
Historique:
received: 10 03 2022
accepted: 12 04 2022
pubmed: 4 5 2022
medline: 14 7 2022
entrez: 3 5 2022
Statut: ppublish

Résumé

The concept of hepatic induction of drug-metabolizing cytochrome P450s (P450s) by xenobiotics, including therapeutic drugs, was proposed in the early 1960s. A polycyclic aromatic hydrocarbon and phenobarbital have been the two major inducers used to investigate this induction mechanism. Currently, the mechanisms mediated by aryl hydrocarbon receptor and constitutive androstane receptor are well-established. In addition to mammals, insects and fungi also express P450s and induce them following exposure to insecticides. These inductions may have environmental consequences. Finding the molecular mechanism regulating these inductions will be of major interest in the future. SIGNIFICANCE STATEMENT: This paper summarizes present and future of investigations into induction of drug-metabolizing enzymes.

Identifiants

DOI: 10.1124/dmd.122.000891 PMID: 35504657
pubmed: 35504657
pii: dmd.122.000891
doi: 10.1124/dmd.122.000891
doi:

Substances chimiques

Xenobiotics 0
Cytochrome P-450 Enzyme System 9035-51-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1000-1001

Informations de copyright

Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Tsuneo Omura (T)

Department of Molecular Biology, Graduate School of Medicine Science, Kyushu University, Fukuoka, Japan momura2@mxa.mesh.ne.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Perspective of the Induction of Liver...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Perspective of the Induction of Liver...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes codant pour des enzymes › Induction enzymatique › Perspective of the Induction of Liver...
questionsmedicales.fr › Système digestif › Foie › Perspective of the Induction of Liver...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Perspective of the Induction of Liver...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Perspective of the Induction of Liver...
questionsmedicales.fr › Préparations pharmaceutiques › Xénobiotique › Perspective of the Induction of Liver...