Metabolism and Disposition of [

Administration, Oral Animals Cyclopentanes Dogs Enzyme Inhibitors / therapeutic use Feces Infusions, Intravenous Neoplasms / drug therapy Pyrimidines Rats

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
07 2022
Historique:
received: 27 01 2022
accepted: 29 03 2022
pubmed: 4 5 2022
medline: 9 7 2022
entrez: 3 5 2022
Statut: ppublish

Résumé

Metabolism and disposition of pevonedistat, an investigational, first-in-class inhibitor of the NEDD8-activating enzyme (NAE), were characterized in patients with advanced solid tumors after intravenous infusion of [

Identifiants

DOI: 10.1124/dmd.122.000842 PMID: 35504658
pubmed: 35504658
pii: dmd.122.000842
doi: 10.1124/dmd.122.000842
doi:

Substances chimiques

Cyclopentanes 0
Enzyme Inhibitors 0
Pyrimidines 0
pevonedistat S3AZD8D215

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

989-997

Informations de copyright

Copyright © 2022 by The Author(s).

Auteurs

Jayaprakasam Bolleddula (J)

Takeda Development Center Americas, Inc., Lexington, Massachusetts swapan@bostonpharmaceuticals.com bolleddulajp@yahoo.com.

Hao Chen (H)

Takeda Development Center Americas, Inc., Lexington, Massachusetts.

Lawrence Cohen (L)

Takeda Development Center Americas, Inc., Lexington, Massachusetts.

Xiaofei Zhou (X)

Takeda Development Center Americas, Inc., Lexington, Massachusetts.

Sandeepraj Pusalkar (S)

Takeda Development Center Americas, Inc., Lexington, Massachusetts.

Allison Berger (A)

Takeda Development Center Americas, Inc., Lexington, Massachusetts.

Farhad Sedarati (F)

Takeda Development Center Americas, Inc., Lexington, Massachusetts.

Karthik Venkatakrishnan (K)

Takeda Development Center Americas, Inc., Lexington, Massachusetts.

Swapan K Chowdhury (SK)

Takeda Development Center Americas, Inc., Lexington, Massachusetts swapan@bostonpharmaceuticals.com bolleddulajp@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Metabolism and Disposition of [
questionsmedicales.fr › Eucaryotes › Animaux › Metabolism and Disposition of [
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures alicycliques › Cyclopentanes › Metabolism and Disposition of [
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Metabolism and Disposition of [
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Metabolism and Disposition of [
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › Metabolism and Disposition of [
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Perfusions parentérales › Perfusions veineuses › Metabolism and Disposition of [
questionsmedicales.fr › Tumeurs › Metabolism and Disposition of [
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Metabolism and Disposition of [
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Metabolism and Disposition of [