Epigenetics and ADHD.
Candidate gene
EWAS
Epigenetic
Epigenome
Methylation
Journal
Current topics in behavioral neurosciences
ISSN: 1866-3370
Titre abrégé: Curr Top Behav Neurosci
Pays: Germany
ID NLM: 101535383
Informations de publication
Date de publication:
2022
2022
Historique:
pubmed:
4
5
2022
medline:
6
8
2022
entrez:
3
5
2022
Statut:
ppublish
Résumé
There is robust evidence of genetic susceptibility to Attention-Deficit Hyperactivity Disorder (ADHD); however, there still remains significant variability that is not attributable to genetic factors. The emerging field of epigenetics is beginning to reveal how genotypic expression can be mediated by an array of variables including external environmental exposure, inter-individual developmental variation, and by the genome itself. Epigenetic modification plays a central role in neurobiological and developmental processes, and disturbances to these processes can have implications for a range of mental health problems. Although the field is still in its early days, this chapter will discuss the current standing of epigenetic research into ADHD. Firstly, key relevant epigenetic processes will be discussed. This will be followed by an overview of the key findings to date investigating the role of epigenetics in ADHD. Human studies have included the theory-driven approach of candidate-gene studies (CGS), as well as the increasingly popular exploratory approach of epigenome-wide association studies (EWAS). Overall, the findings are heterogeneous. However, it is possible that with more longitudinal studies and better characterised cohorts, both predictive and protective links between epigenetic processes and ADHD will be revealed.
Identifiants
pubmed: 35505060
doi: 10.1007/7854_2022_339
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
269-289Informations de copyright
© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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