Pulsatile pulmonary artery pressure in a large animal model of chronic thromboembolic pulmonary hypertension: Similarities and differences with human data.

animal models pathophysiology pulmonary hypertension experimental right ventricle function and dysfunction

Journal

Pulmonary circulation
ISSN: 2045-8932
Titre abrégé: Pulm Circ
Pays: United States
ID NLM: 101557243

Informations de publication

Date de publication:
Jan 2022
Historique:
received: 27 04 2021
revised: 27 10 2021
accepted: 20 11 2021
entrez: 4 5 2022
pubmed: 5 5 2022
medline: 5 5 2022
Statut: epublish

Résumé

A striking feature of the human pulmonary circulation is that mean (mPAP) and systolic (sPAP) pulmonary artery pressures (PAPs) are strongly related and, thus, are essentially redundant. According to the empirical formula documented under normotensive and hypertensive conditions (mPAP = 0.61 sPAP + 2 mmHg), sPAP matches ~160%mPAP on average. This attests to the high pulsatility of PAP, as also witnessed by the near equality of PA pulse pressure and mPAP. Our prospective study tested if pressure redundancy and high pulsatility also apply in a piglet model of chronic thromboembolic pulmonary hypertension (CTEPH). At baseline (Week-0, W0), Sham (

Identifiants

pubmed: 35506099
doi: 10.1002/pul2.12017
pii: PUL212017
pmc: PMC9052967
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e12017

Informations de copyright

© 2021 The Authors. Pulmonary Circulation published by Wiley Periodicals LLC on behalf of the Pulmonary Vascular Research Institute.

Déclaration de conflit d'intérêts

The authors declare that there are no conflicts of interest in the field (physiology).

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Auteurs

David Boulate (D)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.

Fanny Loisel (F)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.

Mathieu Coblence (M)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.

Bastien Provost (B)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.

Alban Todesco (A)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.

Benoit Decante (B)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.

Antoine Beurnier (A)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.

Philippe Herve (P)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.

Frédéric Perros (F)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.

Marc Humbert (M)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Service de Pneumologie, Hôpital Bicêtre DMU-THORINO, AP-HP Le Kremlin-Bicêtre France.

Elie Fadel (E)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Pôle Thoracique, Vasculaire et Transplantations Hôpital Marie Lannelongue Le Plessis Robinson France.

Olaf Mercier (O)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Pôle Thoracique, Vasculaire et Transplantations Hôpital Marie Lannelongue Le Plessis Robinson France.

Denis Chemla (D)

Hôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Service d'Explorations Fonctionnelles Multidisciplinaires Bi-site, Hôpitaux Antoine Béclère-Kremlin Bicêtre, Faculté de médecine-Université Paris Saclay DMU-CORREVE, AP-HP Le Kremlin-Bicêtre France.

Classifications MeSH