Hepatosteatosis and Atherosclerotic Plaque at Coronary CT Angiography.

CT Cardiac Coronary Artery Disease Hepatosteatosis Nonalcoholic Fatty Liver Disease Plaque Quantification

Journal

Radiology. Cardiothoracic imaging
ISSN: 2638-6135
Titre abrégé: Radiol Cardiothorac Imaging
Pays: United States
ID NLM: 101748663

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 04 10 2021
revised: 01 03 2022
accepted: 29 03 2022
entrez: 4 5 2022
pubmed: 5 5 2022
medline: 5 5 2022
Statut: epublish

Résumé

To assess the association between nonalcoholic fatty liver disease (NAFLD) and quantitative atherosclerotic plaque at CT. In this post hoc analysis of the prospective Scottish Computed Tomography of the HEART trial (November 2010 to September 2014), hepatosteatosis and coronary artery calcium score were measured at noncontrast CT. Presence of stenoses, visually assessed high-risk plaque, and quantitative plaque burden were assessed at coronary CT angiography. Multivariable models were constructed to assess the impact of hepatosteatosis and cardiovascular risk factors on coronary artery disease. Images from 1726 participants (mean age, 58 years ± 9 [SD]; 974 men) were included. Participants with hepatosteatosis (155 of 1726, 9%) had a higher body mass index, more hypertension and diabetes mellitus, and higher cardiovascular risk scores ( Hepatosteatosis at CT was associated with an increased prevalence of coronary artery disease at CT, but this was not independent of the presence of cardiovascular risk factors.

Identifiants

DOI: 10.1148/ryct.210260 PMID: 35506136 PMC: PMC9059242
pubmed: 35506136
doi: 10.1148/ryct.210260
pmc: PMC9059242
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e210260

Subventions

Organisme : British Heart Foundation
ID : RG/16/10/32375
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/19/46/34445
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/14/78/31020
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/20/10/34966
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/16/14/32023
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/18/5/34216
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/09/002
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/ICRF/20/26002
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/F/21/90010
Pays : United Kingdom

Informations de copyright

© 2022 by the Radiological Society of North America, Inc.

Déclaration de conflit d'intérêts

Disclosures of conflicts of interest: J.C. No relevant relationships. T.D.H. Investigator-sponsored research grant from Gilead Sciences paid to the University of Liverpool to conduct pilot study 2017; payment or honoraria for lectures from Janssen (2019), Gilead Sciences (2018), and Merck (2020) for speaking at an educational event. M.N.M. No relevant relationships. E.T. British Heart Foundation grant (FS/CRTF/20/24086). J.K. No relevant relationships. M.D. No relevant relationships. P.M. No relevant relationships. A.J.M. No relevant relationships. P.D.A. National Heart Foundation of New Zealand Senior Fellowship and Health Research Council of New Zealand Research grants; support from Abbott Vascular for travel provided to attend educational meetings. A.H. BHF Funded Clinical Research Fellowship. S.A. No relevant relationships. A.S.V.S. No relevant relationships. T.P. No relevant relationships. C.W. No relevant relationships. J.R.W.M. Editorial board of Radiology: Cardiothoracic Imaging. G.R. No relevant relationships. E.J.R.v.B. Consulting fee from Contextflow (not related to this work); QCTIS founder/owner (not related to this work); payment or honoraria from AstraZeneca (presentation) and Roche Diagnostics (presentation) (not related to this work); medical advisory board for Aidence and steering committee clinical study for AstraZeneca (not related to this work). E.D.N. Consulting fees from Medneo Diagnostics, Caristo, and Terarecon; secretary of SCCT. L.J.S. No relevant relationships. D.S.B. No relevant relationships. P.J.S. NIH (5R01HL135557); royalties or license from Cedar-Sinai software; consulting fees from IBA; patent (method and system for plaque characterization) US8885905B2; ASNC 2021 meeting chair; SNMMI CVC council vice president. N.L.M. No relevant relationships. M.R.D. No relevant relationships. D.E.N. British Heart Foundation (CH/09/002, RG/16/10/32375, RE/18/5/34216); Wellcome Trust Senior Investigator Award (WT103782AIA); National Institutes of Health (1R01HL148787); Siemens Healthineers educational grant; Toshiba consultancy. S.W.M. No relevant relationships. D.D. Supported in part by the National Institutes of Health/National Heart, Lung, and Blood Institute grant 1R01HL148787-01A1. M.C.W. British Heart Foundation grant (FS/ICRF/20/26002); speakers bureau for Canon Medical Systems; member of board of directors for SCCT; president elect of British Society of Cardiovascular Imaging; editorial board member of Radiology: Cardiothoracic Imaging.

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Auteurs

Jessica Carter (J)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0002-9015-3216

Thomas D Heseltine (TD)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).

Mohammed N Meah (MN)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).

Evangelos Tzolos (E)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0003-0038-043X

Jacek Kwiecinski (J)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).

Mhairi Doris (M)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).

Priscilla McElhinney (P)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0002-7642-6804

Alastair J Moss (AJ)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0003-4123-2070

Philip D Adamson (PD)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0002-6177-956X

Amanda Hunter (A)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).

Shirjel Alam (S)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0002-2099-612X

Anoop S V Shah (ASV)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).

Tania Pawade (T)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).

Chengjia Wang (C)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0003-2345-7364

Jonathan R Weir-McCall (JR)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0001-5842-842X

Giles Roditi (G)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0001-9393-7764

Edwin J R van Beek (EJR)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0002-2777-5071

Edward D Nicol (ED)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).

Leslee J Shaw (LJ)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).

Daniel S Berman (DS)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0002-3793-9578

Piotr J Slomka (PJ)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0002-6110-938X

Nicholas L Mills (NL)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0003-0533-7991

Marc R Dweck (MR)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0001-9847-5917

David E Newby (DE)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0001-7971-4628

Scott W Murray (SW)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).

Damini Dey (D)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0003-2236-6970

Michelle C Williams (MC)

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland EH16 SUF, (J.C., M.N.M., E.T., J.K., M.D., A.J.M., P.D.A., A.H., S.A., A.S.V.S., T.P., C.W., N.L.M., M.R.D., D.E.N., M.C.W.); Liverpool Centre for Cardiovascular Science, Liverpool, England (T.D.H., S.W.M.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.); Biomedical Imaging Research Institute and Division of Artificial Intelligence in Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif (P.M., D.S.B., P.J.S., D.D.); Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.); Department of Radiology, University of Cambridge, Cambridge, England (J.R.W.M.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland (G.R.); Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, Scotland (E.J.R.v.B., M.R.D., D.E.N., M.C.W.); Royal Brompton and Harefield NHS Foundation Trust Departments of Cardiology and Radiology, London, England and the National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, England (E.D.N.); and Icahn School of Medicine, Weill Cornell Medical College, New York, NY (L.J.S.).
ORCID: 0000-0003-3556-2428

Classifications MeSH