Antibody-Dependent Complement Responses toward SARS-CoV-2 Receptor-Binding Domain Immobilized on "Pseudovirus-like" Nanoparticles.
SARS-CoV-2
antibody
complement
iron oxide nanoparticle
opsonization
receptor-binding domain
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
04 May 2022
04 May 2022
Historique:
pubmed:
5
5
2022
medline:
5
5
2022
entrez:
4
5
2022
Statut:
aheadofprint
Résumé
Many aspects of innate immune responses to SARS viruses remain unclear. Of particular interest is the role of emerging neutralizing antibodies against the receptor-binding domain (RBD) of SARS-CoV-2 in complement activation and opsonization. To overcome challenges with purified virions, here we introduce "pseudovirus-like" nanoparticles with ∼70 copies of functional recombinant RBD to map complement responses. Nanoparticles fix complement in an RBD-dependent manner in sera of all vaccinated, convalescent, and naı̈ve donors, but vaccinated and convalescent donors with the highest levels of anti-RBD antibodies show significantly higher IgG binding and higher deposition of the third complement protein (C3). The opsonization
Identifiants
pubmed: 35507641
doi: 10.1021/acsnano.2c02794
pmc: PMC9092195
mid: NIHMS1922546
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R56 AI153488
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400008C
Pays : United States
Organisme : NIAAA NIH HHS
ID : R24 AA013162
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA013162
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI149655
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI154959
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB022040
Pays : United States
Références
J Control Release. 2021 Oct 10;338:548-556
pubmed: 34481928
Nature. 2022 Jun;606(7914):576-584
pubmed: 35385861
Viruses. 2021 Feb 17;13(2):
pubmed: 33671334
Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):25018-25025
pubmed: 32943538
Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11893-7
pubmed: 18697946
Vaccine. 2021 Apr 28;39(18):2489-2490
pubmed: 33824042
Bioconjug Chem. 2017 Nov 15;28(11):2747-2755
pubmed: 29090582
Springer Semin Immunopathol. 2005 Nov;27(3):286-98
pubmed: 16267649
Nat Nanotechnol. 2017 May;12(4):387-393
pubmed: 27992410
ACS Nano. 2020 Sep 22;14(9):12234-12247
pubmed: 32845122
Sci Rep. 2020 Sep 14;10(1):14991
pubmed: 32929138
Nature. 2020 Dec;588(7838):498-502
pubmed: 32805734
J Immunol. 2014 Feb 1;192(3):1220-30
pubmed: 24367026
Emerg Microbes Infect. 2018 Apr 24;7(1):77
pubmed: 29691378
Emerg Microbes Infect. 2015 May;4(5):e28
pubmed: 26060601
Nat Commun. 2020 Nov 18;11(1):5885
pubmed: 33208793
J Immunol. 2012 Jan 15;188(2):885-91
pubmed: 22156595
Immunol Res. 2002;25(1):75-95
pubmed: 11868935
Emerg Infect Dis. 2005 Mar;11(3):411-6
pubmed: 15757556
Nat Commun. 2021 Aug 11;12(1):4858
pubmed: 34381048
Front Immunol. 2016 Oct 10;7:418
pubmed: 27777575
Nat Commun. 2019 May 27;10(1):2331
pubmed: 31133680
J Immunol. 2020 Sep 15;205(6):1488-1495
pubmed: 32699160
J Immunol Methods. 2010 Jan 31;352(1-2):195-7
pubmed: 19909755
Adv Drug Deliv Rev. 2011 Sep 16;63(12):1000-7
pubmed: 21689701
Bioconjug Chem. 2020 Jul 15;31(7):1844-1856
pubmed: 32598839
Front Immunol. 2017 Feb 15;8:151
pubmed: 28239384
Mol Pharm. 2019 Oct 7;16(10):4274-4281
pubmed: 31556296
ACS Nano. 2022 Feb 22;16(2):1689-1707
pubmed: 35138808
Nat Med. 1995 Mar;1(3):237-43
pubmed: 7585040
Biochem J. 1981 May 1;195(2):471-80
pubmed: 7316962
J Immunol. 2010 Feb 15;184(4):1931-45
pubmed: 20053940
Nat Rev Immunol. 2020 Jun;20(6):343-344
pubmed: 32327719
Bio Protoc. 2016 Dec 5;6(23):
pubmed: 28018942
Science. 2020 Sep 18;369(6510):1501-1505
pubmed: 32703906
Blood. 2020 Oct 29;136(18):2080-2089
pubmed: 32877502
Cell. 2020 Aug 6;182(3):722-733.e11
pubmed: 32645327
Scand J Immunol. 1989 Aug;30(2):175-83
pubmed: 2762767
Front Immunol. 2020 Oct 12;11:567365
pubmed: 33154748
Mol Immunol. 2019 Jan;105:150-164
pubmed: 30513451
Arthritis Rheum. 2008 Oct;58(10):3081-9
pubmed: 18821684
Commun Biol. 2021 Jan 29;4(1):129
pubmed: 33514825
J Clin Microbiol. 2021 May 19;59(6):
pubmed: 33795412
Science. 2020 Dec 4;370(6521):1227-1230
pubmed: 33115920
ACS Nano. 2021 Feb 23;15(2):2738-2752
pubmed: 33464829
J Virol. 2007 Apr;81(7):3487-94
pubmed: 17202212
EMBO Mol Med. 2020 Aug 7;12(8):e12642
pubmed: 32559343
J Occup Environ Med. 2021 Mar 1;63(3):191-198
pubmed: 33298759
J Immunol. 2007 Sep 15;179(6):4101-9
pubmed: 17785849
J Immunol. 1984 Mar;132(3):1435-9
pubmed: 6693771
J Immunol. 1981 Jan;126(1):7-10
pubmed: 6778918
Front Microbiol. 2017 Jun 16;8:1117
pubmed: 28670306
Nature. 1988 Apr 21;332(6166):738-40
pubmed: 3258649
Nature. 2020 Dec;588(7839):682-687
pubmed: 33045718
Nat Nanotechnol. 2019 Mar;14(3):260-268
pubmed: 30643271
Nat Immunol. 2022 Feb;23(2):275-286
pubmed: 35102342
Nat Immunol. 2010 Sep;11(9):785-97
pubmed: 20720586
J Immunol. 1994 Sep 15;153(6):2729-35
pubmed: 8077677
Nanoscale. 2021 Aug 14;13(30):12865-12873
pubmed: 34254633
Front Mol Biosci. 2021 Apr 22;8:671633
pubmed: 33968996
Nat Commun. 2020 Nov 27;11(1):6044
pubmed: 33247152
JAMA. 2021 May 11;325(18):1896-1898
pubmed: 33739374
Science. 2021 Sep 17;373(6561):1372-1377
pubmed: 34385356
Blood. 2001 Apr 15;97(8):2478-86
pubmed: 11290613