PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms.

Alzheimer Disease / metabolism Animals Brain / metabolism Cell Line, Tumor Mice Phosphoglycerate Dehydrogenase / genetics RNA, Messenger / genetics Serine / metabolism

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
03 05 2022
Historique:
received: 10 01 2021
revised: 26 09 2021
accepted: 10 02 2022
entrez: 4 5 2022
pubmed: 5 5 2022
medline: 7 5 2022
Statut: ppublish

Résumé

Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.

Identifiants

DOI: 10.1016/j.cmet.2022.02.008 PMID: 35508105 PMC: PMC9531314
pubmed: 35508105
pii: S1550-4131(22)00052-3
doi: 10.1016/j.cmet.2022.02.008
pmc: PMC9531314
mid: NIHMS1838088
pii:
doi:

Substances chimiques

RNA, Messenger 0
Serine 452VLY9402
Phosphoglycerate Dehydrogenase EC 1.1.1.95

Types de publication

Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

651-653

Subventions

Organisme : NCI NIH HHS
ID : UG3 CA256960
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA052769
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062429
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016573
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM138852
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG065675
Pays : United States
Organisme : NINDS NIH HHS
ID : K08 NS090633
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests S.Z. is a founder and board member of Genemo, Inc.

Références

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20736-20742
pubmed: 31548413
Curr Biol. 2020 May 18;30(10):1771-1782.e3
pubmed: 32220323
Science. 2019 Aug 9;365(6453):559-565
pubmed: 31395777
Cell Metab. 2020 Mar 3;31(3):503-517.e8
pubmed: 32130882
J Biol Chem. 2010 Dec 31;285(53):41380-90
pubmed: 20966073
Front Psychiatry. 2018 Feb 05;9:14
pubmed: 29459833
Nature. 2019 Jun;570(7761):332-337
pubmed: 31042697
J Neurosci. 2008 Dec 31;28(53):14486-91
pubmed: 19118183
Alzheimers Dement. 2016 Jun;12(6):654-68
pubmed: 26772638
Cell Syst. 2017 Jan 25;4(1):60-72.e4
pubmed: 27989508

Auteurs

Xu Chen (X)

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. Electronic address: x1chen@health.ucsd.edu.

Riccardo Calandrelli (R)

Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.

John Girardini (J)

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.

Zhangming Yan (Z)

Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.

Zhiqun Tan (Z)

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine School of Medicine, Irvine, CA, USA; Department of Anatomy and Neurobiology, University of California, Irvine School of Medicine, Irvine, CA, USA.

Xiangmin Xu (X)

Department of Anatomy and Neurobiology, University of California, Irvine School of Medicine, Irvine, CA, USA.

Annie Hiniker (A)

Department of Pathology, University of California, San Diego, La Jolla, CA, USA.

Sheng Zhong (S)

Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA; Genemo, Inc., San Diego, CA, USA. Electronic address: szhong@ucsd.edu.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › PHGDH expression increases with progression of...
questionsmedicales.fr › Eucaryotes › Animaux › PHGDH expression increases with progression of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › PHGDH expression increases with progression of...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › PHGDH expression increases with progression of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › PHGDH expression increases with progression of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › Carbohydrate dehydrogenases › Phosphoglycerate dehydrogenase › PHGDH expression increases with progression of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › PHGDH expression increases with progression of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Sérine › PHGDH expression increases with progression of...