Tbx2 is a master regulator of inner versus outer hair cell differentiation.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
07
05
2021
accepted:
21
03
2022
pubmed:
5
5
2022
medline:
18
5
2022
entrez:
4
5
2022
Statut:
ppublish
Résumé
The cochlea uses two types of mechanosensory cell to detect sounds. A single row of inner hair cells (IHCs) synapse onto neurons to transmit sensory information to the brain, and three rows of outer hair cells (OHCs) selectively amplify auditory inputs
Identifiants
pubmed: 35508658
doi: 10.1038/s41586-022-04668-3
pii: 10.1038/s41586-022-04668-3
pmc: PMC9803360
mid: NIHMS1845286
doi:
Substances chimiques
T-Box Domain Protein 2
0
T-Box Domain Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
298-303Subventions
Organisme : NCI NIH HHS
ID : P30 CA060553
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC015903
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC017482
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC019834
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
Références
Dallos, P. In Proceedings of the 9th International Symposium on Hearing (eds Cazals, Y. et al.) 3–17 (Elsevier, 1992).
Wiwatpanit, T. et al. Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1. Nature 563, 691–695 (2018).
doi: 10.1038/s41586-018-0570-8
Chessum, L. et al. Helios is a key transcriptional regulator of outer hair cell maturation. Nature 563, 696–700 (2018).
doi: 10.1038/s41586-018-0728-4
Lorenzen, S. M., Duggan, A., Osipovich, A. B., Magnuson, M. A. & García-Añoveros, J. Insm1 promotes neurogenic proliferation in delaminated otic progenitors. Mech. Dev. 138, 233–245 (2015).
doi: 10.1016/j.mod.2015.11.001
Kaiser, M. et al. Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development 148, dev195651 (2021).
doi: 10.1242/dev.195651
Chen, Y. et al. The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2. Mol. Cell. Biochem. 415, 103–109 (2016).
doi: 10.1007/s11010-016-2680-7
Aydoğdu, N. et al. TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme. Development 145, dev171827 (2018).
doi: 10.1242/dev.171827
Wojahn, I., Lüdtke, T. H., Christoffels, V. M., Trowe, M.-O. & Kispert, A. TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung. Respir. Res. 20, 292 (2019).
doi: 10.1186/s12931-019-1264-y
Wakker, V. et al. Generation of mice with a conditional null allele for Tbx2. Genesis 48, 195–199 (2010).
pubmed: 20095052
Yang, H., Xie, X., Deng, M., Chen, X. & Gan, L. Generation and characterization of Atoh1-Cre knock-in mouse line. Genesis 48, 407–413 (2010).
doi: 10.1002/dvg.20633
Yang, H. et al. Gfi1-Cre knock-in mouse line: a tool for inner ear hair cell-specific gene deletion. Genesis 48, 400–406 (2010).
doi: 10.1002/dvg.20632
Sekerková, G., Richter, C.-P. & Bartles, J. R. Roles of the espin actin-bundling proteins in the morphogenesis and stabilization of hair cell stereocilia revealed in CBA/CaJ congenic jerker mice. PLoS Genet. 7, e1002032 (2011).
doi: 10.1371/journal.pgen.1002032
Nielsen, D. W. & Slepecky, N. Stereocilia. in Neurobiology of Hearing: The Cochlea (eds Altschuler, R. A. et al.) 23–46 (Raven Press, 1986).
Ratzan, E. M., Moon, A. M. & Deans, M. R. Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle. Development 147, dev192849 (2020).
doi: 10.1242/dev.192849
Webber, J. L. et al. Axodendritic versus axosomatic cochlear efferent termination is determined by afferent type in a hierarchical logic of circuit formation. Sci. Adv. 7, eabd8637 (2021).
doi: 10.1126/sciadv.abd8637
Dabdoub, A. et al. Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc. Natl Acad. Sci. USA 105, 18396–18401 (2008).
doi: 10.1073/pnas.0808175105
Kempfle, J. S., Turban, J. L. & Edge, A. S. B. Sox2 in the differentiation of cochlear progenitor cells. Sci. Rep. 6, 23293 (2016).
doi: 10.1038/srep23293
Cox, B. C. et al. Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo. Development 141, 816–829 (2014).
doi: 10.1242/dev.103036
Hu, L. et al. Diphtheria toxin-induced cell death triggers Wnt-dependent hair cell regeneration in neonatal mice. J. Neurosci. 36, 9479–9489 (2016).
doi: 10.1523/JNEUROSCI.2447-15.2016
Bramhall, N. F., Shi, F., Arnold, K., Hochedlinger, K. & Edge, A. S. B. Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. Stem Cell Rep. 2, 311–322 (2014).
doi: 10.1016/j.stemcr.2014.01.008
Liu, H. et al. Cell-specific transcriptome analysis shows that adult pillar and Deiters’ cells express genes encoding machinery for specializations of cochlear hair cells. Front. Mol. Neurosci. 11, 356 (2018).
doi: 10.3389/fnmol.2018.00356
Liu, H. et al. Characterization of transcriptomes of cochlear inner and outer hair cells. J. Neurosci. 34, 11085–11095 (2014).
doi: 10.1523/JNEUROSCI.1690-14.2014
Jia, S., Yang, S., Guo, W. & He, D. Z. Z. Fate of mammalian cochlear hair cells and stereocilia after loss of the stereocilia. J. Neurosci. 29, 15277–15285 (2009).
doi: 10.1523/JNEUROSCI.3231-09.2009
Wang, Y., Hirose, K. & Liberman, M. C. Dynamics of noise-induced cellular injury and repair in the mouse cochlea. J. Assoc. Res. Otolaryngol. 3, 248–268 (2002).
doi: 10.1007/s101620020028
Landegger, L. D. et al. A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nat. Biotechnol. 35, 280–284 (2017).
doi: 10.1038/nbt.3781
Coffin, A., Kelley, M., Manley, G. A. & Popper, A. N. Evolution of sensory hair cells. in Evolution of the Vertebrate Auditory System, Vol. 22 (eds Manley, G. A. et al.) 55–94 (Springer, 2004).
Madisen, L. et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat. Neurosci. 13, 133–140 (2010).
doi: 10.1038/nn.2467
Haque, K. D., Pandey, A. K., Kelley, M. W. & Puligilla, C. Culture of embryonic mouse cochlear explants and gene transfer by electroporation. J. Vis. Exp. 12, 52260 (2015).
Pearce, M., Richter, C.-P. & Cheatham, M. A. A reconsideration of sound calibration in the mouse. J. Neurosci. Meth. 106, 57–67 (2001).
doi: 10.1016/S0165-0270(01)00329-6
Neely, S. T. & Liu, Z. EMAV: Otoacoustic Emission Averager. Technical memo no. 17 (Boy’s Town National Research Hospital, 1994).
Santos-Sacchi, J., Kakehata, S. & Takahashi, S. Effects of membrane potential on the voltage dependence of motility‐related charge in outer hair cells of the guinea‐pig. J. Physiol. 510, 225–235 (1998).
doi: 10.1111/j.1469-7793.1998.225bz.x
Homma, K. & Dallos, P. Evidence that prestin has at least two voltage-dependent steps. J. Biol. Chem. 286, 2297–2307 (2011).
doi: 10.1074/jbc.M110.185694