Establishment of tissue-resident immune populations in the fetus.
Embryogenesis
Fetal immunity
Immune ontogeny
Prenatal development
Journal
Seminars in immunopathology
ISSN: 1863-2300
Titre abrégé: Semin Immunopathol
Pays: Germany
ID NLM: 101308769
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
23
01
2022
accepted:
17
03
2022
pubmed:
5
5
2022
medline:
2
12
2022
entrez:
4
5
2022
Statut:
ppublish
Résumé
The immune system establishes during the prenatal period from distinct waves of stem and progenitor cells and continuously adapts to the needs and challenges of early postnatal and adult life. Fetal immune development not only lays the foundation for postnatal immunity but establishes functional populations of tissue-resident immune cells that are instrumental for fetal immune responses amidst organ growth and maturation. This review aims to discuss current knowledge about the development and function of tissue-resident immune populations during fetal life, focusing on the brain, lung, and gastrointestinal tract as sites with distinct developmental trajectories. While recent progress using system-level approaches has shed light on the fetal immune landscape, further work is required to describe precise roles of prenatal immune populations and their migration and adaptation to respective organ environments. Defining points of prenatal susceptibility to environmental challenges will support the search for potential therapeutic targets to positively impact postnatal health.
Identifiants
pubmed: 35508672
doi: 10.1007/s00281-022-00931-x
pii: 10.1007/s00281-022-00931-x
pmc: PMC9067556
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
747-766Subventions
Organisme : NICHD NIH HHS
ID : K99 HD105016
Pays : United States
Organisme : NICHD NIH HHS
ID : P01 HD106414
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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