Evolution of the human pathogenic lifestyle in fungi.


Journal

Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869

Informations de publication

Date de publication:
05 2022
Historique:
received: 13 08 2021
accepted: 25 03 2022
entrez: 4 5 2022
pubmed: 5 5 2022
medline: 7 5 2022
Statut: ppublish

Résumé

Fungal pathogens cause more than a billion human infections every year, resulting in more than 1.6 million deaths annually. Understanding the natural history and evolutionary ecology of fungi is helping us understand how disease-relevant traits have repeatedly evolved. Different types and mechanisms of genetic variation have contributed to the evolution of fungal pathogenicity and specific genetic differences distinguish pathogens from non-pathogens. Insights into the traits, genetic elements, and genetic and ecological mechanisms that contribute to the evolution of fungal pathogenicity are crucial for developing strategies to both predict emergence of fungal pathogens and develop drugs to combat them.

Identifiants

pubmed: 35508719
doi: 10.1038/s41564-022-01112-0
pii: 10.1038/s41564-022-01112-0
pmc: PMC9097544
mid: NIHMS1798112
doi:

Types de publication

Journal Article Review Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

607-619

Subventions

Organisme : NIAID NIH HHS
ID : R56 AI146096
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153356
Pays : United States

Informations de copyright

© 2022. Springer Nature Limited.

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Auteurs

Antonis Rokas (A)

Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA. antonis.rokas@vanderbilt.edu.
Vanderbilt Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA. antonis.rokas@vanderbilt.edu.

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