Chicken heterophils extracellular traps act as early effectors against cyclopiazonic acid dependent upon NADPH oxidase, ROS and glycolysis.
Chicken
Cyclopiazonic acid
Glycolysis
Heterophil extracellular traps
ROS
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
25
12
2021
accepted:
14
03
2022
pubmed:
5
5
2022
medline:
3
6
2022
entrez:
4
5
2022
Statut:
ppublish
Résumé
Cyclopiazonic acid (CPA) is a secondary metabolite produced by Aspergillus and Penicillium, which is present in contaminated crops and food, causing severe toxicity to humans and animals. Heterophil extracellular traps (HETs) are a novel host innate immune mechanism of chicken heterophils against pathogen infection. However, whether CPA can cause immunotoxicity of heterophils on HETs release remains unclear. Here, we attempt to detect the effects of CPA on HETs release, and further investigate the molecular mechanisms underlying these processes. We exposed heterophils to 2.5, 5, 10 μM CPA for 90 min. The results showed that CPA induced the release of HETs in heterophils, consisting of DNA-modified citrullinated histone 3 and elastase. The quantitative analysis of HETs content was positively correlated with CPA concentration. CPA also promoted reactive oxygen species production and phosphorylation of ERK
Identifiants
pubmed: 35508807
doi: 10.1007/s00204-022-03277-3
pii: 10.1007/s00204-022-03277-3
doi:
Substances chimiques
Indoles
0
Reactive Oxygen Species
0
NADPH Oxidases
EC 1.6.3.-
cyclopiazonic acid
X9TLY4580Z
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2113-2122Subventions
Organisme : Guangdong Basic and Applied Basic Research Foundation
ID : 2019A1515110524
Organisme : National Natural Science Foundation of China
ID : 32002309
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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