Periosteum-induced ossification effect in skull defect through interleukin-8 and NF-κB pathway: An experimental study with
Cranioplasty
Interleukin-8
NF-κB
Periosteum flap
Journal
Surgical neurology international
ISSN: 2229-5097
Titre abrégé: Surg Neurol Int
Pays: United States
ID NLM: 101535836
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
01
2022
accepted:
07
03
2022
entrez:
5
5
2022
pubmed:
6
5
2022
medline:
6
5
2022
Statut:
epublish
Résumé
The purpose of this study was to analyze the response of inflammatory cytokines interleukin-8 (IL-8) and NF-κB to the closure of skull defect with periosteum as a scaffolding material in bone healing used after surgery. Thirty Histological examination showed a more well-developed formation of woven bone in the periosteum group. Immunohistochemical examinations showed that the use of periosteum in the closure of skull defects reduced the NF-κB and IL-8 response which affected the ossification process. The experiment showed that the use of periosteum was linked with IL-8 and NF-κB downregulation toward ossification effects at any point throughout the trial. Periosteum usage might be beneficial as a scaffolding material in bone healing for autograft cranioplasty in animal model and could be applied to clinical practice.
Sections du résumé
Background
UNASSIGNED
The purpose of this study was to analyze the response of inflammatory cytokines interleukin-8 (IL-8) and NF-κB to the closure of skull defect with periosteum as a scaffolding material in bone healing used after surgery.
Methods
UNASSIGNED
Thirty
Results
UNASSIGNED
Histological examination showed a more well-developed formation of woven bone in the periosteum group. Immunohistochemical examinations showed that the use of periosteum in the closure of skull defects reduced the NF-κB and IL-8 response which affected the ossification process.
Conclusion
UNASSIGNED
The experiment showed that the use of periosteum was linked with IL-8 and NF-κB downregulation toward ossification effects at any point throughout the trial. Periosteum usage might be beneficial as a scaffolding material in bone healing for autograft cranioplasty in animal model and could be applied to clinical practice.
Identifiants
pubmed: 35509533
doi: 10.25259/SNI_62_2022
pii: 10.25259/SNI_62_2022
pmc: PMC9062897
doi:
Types de publication
Journal Article
Langues
eng
Pagination
140Informations de copyright
Copyright: © 2022 Surgical Neurology International.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Immunol Res. 2016 Dec;64(5-6):1195-1206
pubmed: 27629117
Int J Dermatol. 2011 Sep;50(9):1058-66
pubmed: 22126865
Front Endocrinol (Lausanne). 2017 Mar 02;8:39
pubmed: 28303118
J Neurosurg. 2015 Jul;123(1):182-8
pubmed: 25768830
J Bone Miner Res. 2013 Apr;28(4):711-22
pubmed: 23436579
Osteoporos Int. 2013 Sep;24(9):2377-86
pubmed: 23468073
Injury. 2007 Oct;38(10):1115-30
pubmed: 17889870
Exp Ther Med. 2012 Feb;3(2):231-236
pubmed: 22969874