Does Serum Osteocalcin Level Affect Carotid Atherosclerosis in Post-Menopausal Diabetic Females? A Case-Control Study.
atherosclerosis
diabetes
glycated hemoglobin
lipid
osteocalcin
Journal
International journal of general medicine
ISSN: 1178-7074
Titre abrégé: Int J Gen Med
Pays: New Zealand
ID NLM: 101515487
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
12
2021
accepted:
11
04
2022
entrez:
5
5
2022
pubmed:
6
5
2022
medline:
6
5
2022
Statut:
epublish
Résumé
To determine the association between serum osteocalcin and carotid intima media thickness (CIMT) in a group of post-menopausal females with type 2 diabetes (T2DM). This cross-sectional study enrolled 75 postmenopausal women with T2DM and 40 age matched postmenopausal healthy females. Age, body mass index, blood pressure were recorded for all subjects. Laboratory tests including fasting blood glucose (FBG), glycated hemoglobin (HbA1c) and lipid profile were measured. Serum osteocalcin was measured using ELISA. Bone mineral density (BMD) was measured by DEXA scan. CIMT was assessed with B-mode ultrasonography. Patients with T2DM had significantly lower serum osteocalcin compared to control (63.73±27.20 vs 136.16±21.96 pg/mL, In this study, Postmenopausal women with diabetes had significantly lower osteocalcin compared to non-diabetic women. Although serum osteocalcin was negatively correlated with CIMT, multivariate regression analysis revealed that osteocalcin level was only independently related to worse glycemic parameters in postmenopausal women with T2DM.
Identifiants
pubmed: 35509602
doi: 10.2147/IJGM.S353492
pii: 353492
pmc: PMC9059994
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4513-4523Informations de copyright
© 2022 Naguib et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
JAMA. 2011 Jun 1;305(21):2184-92
pubmed: 21632482
Cardiovasc Diabetol. 2013 Jan 23;12:22
pubmed: 23342952
J Diabetes Res. 2017;2017:9021314
pubmed: 28695134
Am Heart J. 2003 Aug;146(2):351-8
pubmed: 12891207
PLoS One. 2015 Sep 29;10(9):e0138693
pubmed: 26418005
Diabetol Metab Syndr. 2020 Aug 17;12:72
pubmed: 32821293
Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5266-70
pubmed: 18362359
Int J Endocrinol. 2013;2013:842598
pubmed: 23533407
Sci Rep. 2020 Feb 4;10(1):1840
pubmed: 32020009
J Clin Invest. 2014 Apr;124(4):1465-7
pubmed: 24642463
Diabet Med. 2013 Mar;30(3):309-17
pubmed: 22913521
Diabetes Obes Metab. 2018 Aug;20(8):1817-1828
pubmed: 29687585
Lipids Health Dis. 2017 Jul 21;16(1):139
pubmed: 28732499
Arthritis Res Ther. 2019 Jan 10;21(1):15
pubmed: 30630495
J Nat Sci Biol Med. 2017 Jan-Jun;8(1):94-98
pubmed: 28250682
J Clin Endocrinol Metab. 2009 Jan;94(1):45-9
pubmed: 18984661
Clin Diabetes Endocrinol. 2018 Apr 25;4:9
pubmed: 29721333
Cerebrovasc Dis. 2012;34(4):290-6
pubmed: 23128470
Arq Gastroenterol. 2010 Apr-Jun;47(2):165-9
pubmed: 20721461
Clin Rheumatol. 2005 Sep;24(5):493-6
pubmed: 15747054
Atherosclerosis. 2014 Mar;233(1):272-7
pubmed: 24529156
J Clin Densitom. 2020 Jan - Mar;23(1):29-36
pubmed: 31101413
Eur J Endocrinol. 2009 Nov;161(5):723-9
pubmed: 19671707
Cell. 2007 Aug 10;130(3):456-69
pubmed: 17693256
Braz J Med Biol Res. 2007 Apr;40(4):435-42
pubmed: 17401486
Clin Cases Miner Bone Metab. 2008 Jan;5(1):19-34
pubmed: 22460842
Clin Endocrinol (Oxf). 2011 Aug;75(2):196-201
pubmed: 21521333
Clin Interv Aging. 2021 Jun 09;16:1057-1070
pubmed: 34135578
Curr Health Sci J. 2019 Jan-Mar;45(1):47-51
pubmed: 31297262
Nutrients. 2018 Oct 04;10(10):
pubmed: 30287742
Clin Chim Acta. 2008 Oct;396(1-2):66-9
pubmed: 18657532
Osteoporos Int. 2004 May;15(5):389-95
pubmed: 14661073
Bone Res. 2018 May 24;6:16
pubmed: 29844945
J Clin Med. 2019 Jan 16;8(1):
pubmed: 30654523
World J Diabetes. 2015 Oct 10;6(13):1246-58
pubmed: 26468341
Arch Med Sci. 2011 Apr;7(2):179-88
pubmed: 22291755
Diabetes Res Clin Pract. 2008 Dec;82(3):353-8
pubmed: 18950889
PLoS One. 2016 May 05;11(5):e0154740
pubmed: 27149062
Eur J Endocrinol. 2010 Aug;163(2):265-72
pubmed: 20501596
J Endocrinol Invest. 2014 Jul;37(7):661-6
pubmed: 24859912
Front Endocrinol (Lausanne). 2013 Aug 26;4:106
pubmed: 23986744
J Bone Miner Res. 2009 May;24(5):785-91
pubmed: 19063687
Sci Rep. 2019 Nov 22;9(1):17353
pubmed: 31757981
J Clin Invest. 2010 Jan;120(1):357-68
pubmed: 20038793
Horm Metab Res. 2014 May;46(5):341-7
pubmed: 24554534
HSS J. 2010 Feb;6(1):85-94
pubmed: 19763695
World J Diabetes. 2017 Jan 15;8(1):11-17
pubmed: 28138360
Diabetes Res Clin Pract. 2008 Mar;79(3):482-9
pubmed: 18006169