Plin5, a New Target in Diabetic Cardiomyopathy.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
01
2022
revised:
14
03
2022
accepted:
06
04
2022
entrez:
5
5
2022
pubmed:
6
5
2022
medline:
7
5
2022
Statut:
epublish
Résumé
Abnormal lipid accumulation is commonly observed in diabetic cardiomyopathy (DC), which can create a lipotoxic microenvironment and damage cardiomyocytes. Lipid toxicity is an important pathogenic factor due to abnormal lipid accumulation in DC. As a lipid droplet (LD) decomposition barrier, Plin5 can protect LDs from lipase decomposition and regulate lipid metabolism, which is involved in the occurrence and development of cardiovascular diseases. In recent years, studies have shown that Plin5 expression is involved in the pathogenesis of DC lipid toxicity, such as oxidative stress, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and insulin resistance (IR) and has become a key target of DC research. Therefore, understanding the relationship between Plin5 and DC progression as well as the mechanism of this process is crucial for developing new therapeutic approaches and exploring new therapeutic targets. This review is aimed at exploring the latest findings and roles of Plin5 in lipid metabolism and DC-related pathogenesis, to explore possible clinical intervention approaches.
Identifiants
pubmed: 35509833
doi: 10.1155/2022/2122856
pmc: PMC9060988
doi:
Substances chimiques
Lipids
0
Perilipin-5
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2122856Informations de copyright
Copyright © 2022 Xiangning Cui et al.
Déclaration de conflit d'intérêts
The authors declare that they do not have anything to disclose regarding conflict of interest with respect to this manuscript.
Références
Free Radic Biol Med. 2008 Aug 1;45(3):231-41
pubmed: 18482593
Liver Int. 2020 Oct;40(10):2427-2438
pubmed: 32339374
J Lipid Res. 2013 Apr;54(4):953-65
pubmed: 23345411
J Biol Chem. 2009 Dec 11;284(50):34538-44
pubmed: 19850935
Nat Commun. 2021 Jun 3;12(1):3320
pubmed: 34083525
Cell Metab. 2013 Aug 6;18(2):162-85
pubmed: 23791483
Crit Rev Biochem Mol Biol. 2014 Jul-Aug;49(4):304-26
pubmed: 25039762
J Biol Chem. 2011 May 6;286(18):15707-15
pubmed: 21393244
Physiol Rep. 2013 Sep;1(4):e00084
pubmed: 24303154
Curr Biol. 2014 Mar 17;24(6):609-20
pubmed: 24613307
Dev Cell. 2008 May;14(5):661-73
pubmed: 18477450
Diabetes Care. 2013 Aug;36 Suppl 2:S175-9
pubmed: 23882043
Cell Calcium. 2000 Jul;28(1):1-21
pubmed: 10942700
Mol Metab. 2014 Jun 14;3(6):652-63
pubmed: 25161888
Science. 1996 Feb 2;271(5249):665-8
pubmed: 8571133
Nat Rev Cardiol. 2018 Aug;15(8):457-470
pubmed: 29915254
Lab Invest. 2016 Jul;96(7):791-806
pubmed: 27135793
Am J Physiol. 1986 Aug;251(2 Pt 2):H448-54
pubmed: 2943166
J Lipid Res. 2012 Aug;53(8):1482-92
pubmed: 22628613
Physiol Rev. 2011 Jul;91(3):1023-70
pubmed: 21742795
J Clin Endocrinol Metab. 2006 Nov;91(11):4689-95
pubmed: 16926257
Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16454-9
pubmed: 17050683
Diabetologia. 2007 Apr;50(4):752-63
pubmed: 17268797
Autophagy. 2016;12(2):225-44
pubmed: 26902584
Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10878-82
pubmed: 7971976
FEBS Lett. 1999 Jun 11;452(3):355-9
pubmed: 10386621
J Lipid Res. 2020 Mar;61(3):338-350
pubmed: 31932301
Circ Res. 2018 Jun 22;123(1):107-128
pubmed: 29929976
Prostaglandins Leukot Essent Fatty Acids. 1999 Mar;60(3):187-98
pubmed: 10359021
Science. 1994 Aug 5;265(5173):808-11
pubmed: 7914033
Cardiovasc Res. 2008 Apr 1;78(1):79-89
pubmed: 18187461
PLoS One. 2015 Mar 06;10(3):e0118909
pubmed: 25748450
Circulation. 2017 Dec 5;136(23):2248-2266
pubmed: 28942427
Trends Endocrinol Metab. 2015 Mar;26(3):144-52
pubmed: 25682370
J Clin Invest. 2010 Oct;120(10):3443-54
pubmed: 20852389
PLoS One. 2013 Oct 09;8(10):e76836
pubmed: 24130796
J Dairy Sci. 2019 Jan;102(1):833-845
pubmed: 30415861
Hepatol Res. 2005 Oct;33(2):171-3
pubmed: 16214394
J Biol Chem. 2009 Nov 13;284(46):32116-25
pubmed: 19717842
Diabetes. 2006 Dec;55(12):3418-28
pubmed: 17130488
J Thromb Thrombolysis. 2020 Feb;49(2):177-183
pubmed: 31898271
Microcirculation. 2017 Jan;24(1):
pubmed: 27976459
Diabetes. 1994 May;43(5):703-11
pubmed: 8168648
Circ Res. 2016 Mar 18;118(6):1021-40
pubmed: 26987915
Nutrients. 2019 Aug 28;11(9):
pubmed: 31466350
Hepatology. 2015 Mar;61(3):870-82
pubmed: 25179419
Cardiovasc Drugs Ther. 2021 Oct;35(5):1067-1076
pubmed: 33074526
J Biol Chem. 2005 Apr 22;280(16):16456-60
pubmed: 15716268
Lipids Health Dis. 2017 Apr 28;16(1):83
pubmed: 28454542
Nature. 2006 Dec 14;444(7121):875-80
pubmed: 17167476
J Am Coll Cardiol. 2016 Jul 5;68(1):53-63
pubmed: 27364051
Histochem Cell Biol. 2012 Feb;137(2):205-16
pubmed: 22127648
Lancet. 1963 Apr 13;1(7285):785-9
pubmed: 13990765
Metabolism. 2019 Mar;92:71-81
pubmed: 30447223
Curr Opin Pharmacol. 2016 Jun;28:1-7
pubmed: 26921601
J Lipid Res. 2013 Feb;54(2):522-34
pubmed: 23175776
Oxid Med Cell Longev. 2019 Oct 17;2019:8690746
pubmed: 31772713
Circulation. 2019 Apr 16;139(16):1913-1936
pubmed: 30646747
Annu Rev Cell Dev Biol. 2011;27:107-32
pubmed: 21801009
Bot Stud. 2021 May 18;62(1):7
pubmed: 34003397
Nat Cell Biol. 2013 May;15(5):481-90
pubmed: 23624402
Front Physiol. 2016 Apr 12;7:125
pubmed: 27148064
J Biomed Sci. 2017 Jul 27;24(1):50
pubmed: 28750629
Front Pharmacol. 2020 Nov 30;11:587438
pubmed: 33328993
Science. 2006 Aug 25;313(5790):1137-40
pubmed: 16931765
Nutr Metab (Lond). 2019 Jul 30;16:50
pubmed: 31384284
Mol Med. 2010 Jul-Aug;16(7-8):235-46
pubmed: 20386866
Circ Res. 2020 May 22;126(11):1628-1645
pubmed: 32437305
Diabetes. 2008 Nov;57(11):2924-32
pubmed: 18678617
Circ Res. 2008 Aug 15;103(4):343-51
pubmed: 18703786
Eur J Heart Fail. 2019 Jul;21(7):862-873
pubmed: 31033127
Metabolism. 1995 Nov;44(11):1391-6
pubmed: 7476323
J Mol Cell Cardiol. 2012 May;52(5):1019-26
pubmed: 22342406
Clin Sci (Lond). 2005 Mar;108(3):245-53
pubmed: 15563273
Cell. 1999 Jul 9;98(1):115-24
pubmed: 10412986
Nat Commun. 2016 Aug 24;7:12723
pubmed: 27554864
Diabetes. 2009 Nov;58(11):2607-15
pubmed: 19720802
Circ Res. 2018 Feb 16;122(4):624-638
pubmed: 29449364
Diabetes. 2018 Apr;67(4):594-606
pubmed: 29378767
Mol Cell. 2021 Sep 16;81(18):3708-3730
pubmed: 34547235
Mol Cell Endocrinol. 2012 Nov 25;364(1-2):28-35
pubmed: 22902957
J Biol Chem. 2003 Jan 31;278(5):2896-902
pubmed: 12417588
J Mol Endocrinol. 2014 Jun;52(3):R199-222
pubmed: 24577718
Trends Cardiovasc Med. 2002 Apr;12(3):134-8
pubmed: 12007739
N Engl J Med. 2020 Mar 5;382(10):972-973
pubmed: 32130822
Nature. 2009 Apr 23;458(7241):1056-60
pubmed: 19262508
Mol Cell. 2014 May 8;54(3):362-77
pubmed: 24746696
Front Neurosci. 2020 Jan 31;13:1410
pubmed: 32076395
Mol Cell Biochem. 2003 Apr;246(1-2):155-62
pubmed: 12841357
FEBS Lett. 2008 Jan 9;582(1):46-53
pubmed: 18036349
Int J Mol Sci. 2016 Dec 18;17(12):
pubmed: 27999359
Sci Rep. 2016 Dec 06;6:38310
pubmed: 27922115
Br J Pharmacol. 2006 Jul;148(5):619-28
pubmed: 16702987
Antioxid Redox Signal. 2011 Jul 1;15(1):205-18
pubmed: 21050144
Cardiovasc Diabetol. 2021 Jun 11;20(1):121
pubmed: 34116674
Nat Cell Biol. 2012 Jan 22;14(2):177-85
pubmed: 22267086
Biochim Biophys Acta. 2010 Aug;1804(8):1676-83
pubmed: 20005308
Annu Rev Cell Dev Biol. 2017 Oct 6;33:491-510
pubmed: 28793795
Antioxid Redox Signal. 2019 Feb 10;30(5):713-732
pubmed: 29631413
Am J Clin Nutr. 2011 Apr;93(4):884S-90
pubmed: 21289221
Cell Physiol Biochem. 2018;49(1):245-259
pubmed: 30138942
Nat Rev Cardiol. 2018 Apr;15(4):203-214
pubmed: 29143812
N Engl J Med. 2003 Jan 30;348(5):383-93
pubmed: 12556541
J Cell Biol. 2008 Feb 11;180(3):473-82
pubmed: 18250201
Diabetes. 2015 Apr;64(4):1299-310
pubmed: 25392244
Prog Cell Cycle Res. 2003;5:219-24
pubmed: 14593716
J Endocrinol. 2017 Jun;233(3):R131-R143
pubmed: 28381504
Nature. 2016 Jan 21;529(7586):326-35
pubmed: 26791723
Scand J Med Sci Sports. 2015 Dec;25 Suppl 4:60-73
pubmed: 26589119
Am J Cardiol. 1972 Nov 8;30(6):595-602
pubmed: 4263660
Biochem Biophys Res Commun. 1996 Nov 12;228(2):334-40
pubmed: 8920915
Int Heart J. 2021;62(1):197-200
pubmed: 33518659
J Cell Biochem. 2017 Dec 7;:
pubmed: 29215758
Am J Med Sci. 2007 Sep;334(3):197-205
pubmed: 17873534
Diabetes Care. 1991 Mar;14(3):173-94
pubmed: 2044434
Circ Res. 2011 Apr 29;108(9):1122-32
pubmed: 21527742
Nat Rev Drug Discov. 2022 Feb;21(2):115-140
pubmed: 34702991
Endocrinology. 2012 Oct;153(10):4938-45
pubmed: 22919060
J Biol Chem. 2000 Mar 24;275(12):9047-54
pubmed: 10722755
Pharmazie. 2010 Oct;65(10):760-5
pubmed: 21105579
Diabetes. 2009 May;58(5):1067-76
pubmed: 19401434
Diabetologia. 2016 May;59(5):1040-8
pubmed: 26864436
Science. 2016 Jan 15;351(6270):275-281
pubmed: 26816379
Biol Cell. 2011 Jun;103(6):271-85
pubmed: 21729000
PLoS One. 2015 Mar 18;10(3):e0119850
pubmed: 25786112
Cardiovasc Res. 2009 Feb 15;81(3):412-9
pubmed: 18987051
J Am Heart Assoc. 2021 Apr 6;10(7):e016947
pubmed: 33728932
Ann N Y Acad Sci. 2013 Apr;1281:92-105
pubmed: 23363033
Cell. 2012 Feb 3;148(3):624, 624.e1
pubmed: 22304926
Nat Rev Endocrinol. 2016 Mar;12(3):144-53
pubmed: 26678809
Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):800-6
pubmed: 20388489
Heart. 2007 Aug;93(8):903-7
pubmed: 16670100
Am J Physiol Regul Integr Comp Physiol. 2003 Dec;285(6):R1481-9
pubmed: 12947030
Lancet. 2020 Sep 19;396(10254):819-829
pubmed: 32877652
Physiol Rev. 2005 Jul;85(3):1093-129
pubmed: 15987803
Diabetes. 1999 Jun;48(6):1270-4
pubmed: 10342815
J Lipid Res. 2013 Apr;54(4):1092-102
pubmed: 23345410
Nat Rev Cardiol. 2018 Jul;15(7):387-407
pubmed: 29674714
Future Cardiol. 2017 May;13(3):259-278
pubmed: 28581332
Biochem Biophys Res Commun. 2021 Mar 12;544:22-30
pubmed: 33516878
Autophagy. 2015 Nov 2;11(11):2074-2088
pubmed: 26391754
Expert Opin Drug Metab Toxicol. 2018 Dec;14(12):1287-1302
pubmed: 30463454
J Am Coll Cardiol. 2008 Sep 16;52(12):1006-12
pubmed: 18786482
Biochim Biophys Acta. 2015 Feb;1852(2):252-61
pubmed: 24882754
Physiol Rev. 2010 Jan;90(1):207-58
pubmed: 20086077
J Biol Chem. 2014 Oct 24;289(43):29881-91
pubmed: 25157099
FASEB J. 2004 Nov;18(14):1692-700
pubmed: 15522914
J Med Chem. 2012 Feb 23;55(4):1538-52
pubmed: 22242551
Circ Res. 2015 May 22;116(11):1820-34
pubmed: 25999422
Cells. 2019 Oct 11;8(10):
pubmed: 31614673
Diabetes. 2003 Sep;52(9):2389-95
pubmed: 12941780
Bioorg Med Chem Lett. 2012 Jan 15;22(2):1267-70
pubmed: 22217876
J Biol Chem. 2012 Jul 6;287(28):23852-63
pubmed: 22532565
Nature. 2001 Mar 1;410(6824):37-40
pubmed: 11242034
Biochim Biophys Acta. 2013 Apr;1831(4):844-52
pubmed: 23353597
Mol Cell Biochem. 2014 Jan;386(1-2):233-49
pubmed: 24307101
Cell Signal. 2000 Jan;12(1):1-13
pubmed: 10676842
Nat Rev Mol Cell Biol. 2012 Mar 07;13(4):225-238
pubmed: 22395773
Biochem J. 2009 Oct 23;424(1):61-7
pubmed: 19708857
Cell Metab. 2006 Nov;4(5):377-89
pubmed: 17084711
J Biol Chem. 2003 Mar 28;278(13):11303-11
pubmed: 12496284
Cardiovasc Drugs Ther. 2017 Apr;31(2):119-132
pubmed: 28447181
Front Endocrinol (Lausanne). 2020 Mar 31;11:166
pubmed: 32296390
Life Sci. 2014 Nov 24;118(2):173-8
pubmed: 24792520
Genes Dev. 2004 Dec 15;18(24):3066-77
pubmed: 15601821
Diabetes. 2008 Sep;57(9):2280-7
pubmed: 18519800
Ther Adv Endocrinol Metab. 2022 Mar 15;13:20420188221083530
pubmed: 35308180
Mol Endocrinol. 2015 Oct;29(10):1414-25
pubmed: 26296152
Mol Cell Biochem. 2011 May;351(1-2):41-58
pubmed: 21210296
Front Pharmacol. 2021 Sep 23;12:730623
pubmed: 34630108
Sci Rep. 2017 Feb 20;7:42574
pubmed: 28218306
Cardiovasc Diabetol. 2018 Aug 31;17(1):122
pubmed: 30170598
Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E128-37
pubmed: 27189934
PLoS Biol. 2006 Nov;4(11):e374
pubmed: 17090218
Diabetes Care. 2011 May;34 Suppl 2:S145-9
pubmed: 21525446
Circulation. 2018 Mar 20;137(12):e67-e492
pubmed: 29386200
Aging Cell. 2007 Dec;6(6):759-67
pubmed: 17877786
Front Cell Dev Biol. 2020 Dec 15;8:618322
pubmed: 33385001
Diabetes. 2015 Aug;64(8):2757-68
pubmed: 25829453
Circ Res. 2009 Mar 27;104(6):717-9
pubmed: 19325159
Semin Cell Dev Biol. 2020 Dec;108:55-64
pubmed: 32446655
Metabolism. 2021 Aug;121:154803
pubmed: 34090870
Mol Cell. 2020 Feb 20;77(4):810-824.e8
pubmed: 31901447
J Cell Mol Med. 2020 Jan;24(2):1760-1773
pubmed: 31856386
Nature. 2005 Mar 3;434(7029):113-8
pubmed: 15744310
Int J Mol Sci. 2021 Jan 11;22(2):
pubmed: 33440821
Ann N Y Acad Sci. 1999 Nov 18;892:155-68
pubmed: 10842661
PLoS One. 2011 Apr 29;6(4):e19163
pubmed: 21559479
Nat Commun. 2013;4:1871
pubmed: 23695665
J Diabetes Res. 2017;2017:2376893
pubmed: 29318158
Lipids Health Dis. 2010 Jun 02;9:56
pubmed: 20525221
Cardiovasc Res. 2020 Feb 1;116(2):339-352
pubmed: 31166588
Biochim Biophys Acta. 2007 Feb;1771(2):210-27
pubmed: 17234449
J Biol Chem. 2002 Feb 8;277(6):4098-103
pubmed: 11734553
FASEB J. 2016 Aug;30(8):2698-707
pubmed: 27075244
Eur J Pharmacol. 2017 May 5;802:44-51
pubmed: 28238768
Cell Metab. 2008 Oct;8(4):333-41
pubmed: 18840364
Free Radic Biol Med. 2019 Sep;141:372-382
pubmed: 31291602
Diabetologia. 2003 Oct;46(10):1297-312
pubmed: 13680127
Nature. 1994 Dec 22-29;372(6508):739-46
pubmed: 7997261
Nature. 2002 Nov 21;420(6913):333-6
pubmed: 12447443
Cardiovasc Res. 2018 Jul 1;114(8):1132-1144
pubmed: 29554241
J Clin Invest. 2012 Mar;122(3):1109-18
pubmed: 22326951
Diabetes. 2013 Nov;62(11):3887-900
pubmed: 24159000
J Biol Chem. 1996 Oct 4;271(40):24313-6
pubmed: 8798679
Biochim Biophys Acta. 2012 Feb;1821(2):268-78
pubmed: 22063271
Diabetes. 2014 Feb;63(2):605-18
pubmed: 24186865
J Clin Lipidol. 2016 Jan-Feb;10(1):150-60
pubmed: 26892132
PPAR Res. 2014;2014:541394
pubmed: 24523730
J Biol Chem. 2006 May 19;281(20):14232-40
pubmed: 16571721
Arch Biochem Biophys. 2015 Jan 15;566:76-84
pubmed: 25528168
Cell Death Dis. 2011 Nov 10;2:e229
pubmed: 22071634
Circ Res. 2016 May 27;118(11):1736-51
pubmed: 27230639
Cell. 2000 Oct 13;103(2):239-52
pubmed: 11057897
Front Oncol. 2018 May 15;8:160
pubmed: 29868481
Mol Cell Biol. 2014 Jul;34(14):2721-31
pubmed: 24820416
Hypertension. 2015 Dec;66(6):1159-1167
pubmed: 26441470
Autophagy. 2018;14(2):243-251
pubmed: 29165043
Nat Commun. 2020 May 1;11(1):2148
pubmed: 32358497
Cardiovasc Res. 2019 May 1;115(6):1000-1012
pubmed: 30938418
Bioorg Med Chem Lett. 2008 Dec 15;18(24):6357-61
pubmed: 18993064
J Biol Chem. 2015 Jan 16;290(3):1295-306
pubmed: 25418045
Curr Opin Lipidol. 2014 Apr;25(2):110-7
pubmed: 24535284
J Lipid Res. 2011 Dec;52(12):2159-2168
pubmed: 21885430
Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R29-36
pubmed: 22012700
Science. 2003 Dec 5;302(5651):1710-1
pubmed: 14657487
Diabetes. 2015 Feb;64(2):418-26
pubmed: 25614670
Nature. 2003 Mar 13;422(6928):173-6
pubmed: 12629551
Atherosclerosis. 2011 Sep;218(1):13-8
pubmed: 21763654
Am Heart J. 2001 Oct;142(4):684-90
pubmed: 11579360
Heart Fail Rev. 2012 May;17(3):325-44
pubmed: 21626163
J Biol Chem. 2005 Sep 30;280(39):33588-98
pubmed: 16079133
Microbiol Mol Biol Rev. 2004 Jun;68(2):320-44
pubmed: 15187187
Acta Pharmacol Sin. 2018 Jan;39(1):59-73
pubmed: 28770830
Annu Rev Physiol. 1979;41:539-52
pubmed: 155420
J Lipid Res. 2010 Mar;51(3):468-71
pubmed: 19638644
Cardiovasc Res. 2017 Mar 15;113(4):389-398
pubmed: 28395010
Diabetes. 2020 Oct;69(10):2094-2111
pubmed: 32366681
Public Health Nutr. 2007 Oct;10(10A):1132-7
pubmed: 17903321
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Apr;1866(4):158873
pubmed: 33373698
Autophagy. 2015;11(1):46-59
pubmed: 25484077
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1832-7
pubmed: 19181853
Cells. 2013 Apr 26;2(2):266-83
pubmed: 24709700
Diabetes. 2019 Mar;68(3):543-555
pubmed: 30617219
Yale J Biol Med. 2019 Sep 20;92(3):435-452
pubmed: 31543707
Biochim Biophys Acta. 2013 Dec;1833(12):3507-3517
pubmed: 23988738
Autophagy. 2015;11(7):1146-60
pubmed: 26042865
Trends Endocrinol Metab. 2011 Jul;22(7):266-74
pubmed: 21458293
Circ Res. 2008 Feb 29;102(4):401-14
pubmed: 18309108