Allergic sensitization to lipocalins reflects asthma morbidity in dog dander sensitized children.
allergen molecules
asthma
can f
children
dog allergy
lipocalins
nasal provocation testing
Journal
Clinical and translational allergy
ISSN: 2045-7022
Titre abrégé: Clin Transl Allergy
Pays: England
ID NLM: 101576043
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
14
11
2021
revised:
20
03
2022
accepted:
11
04
2022
entrez:
5
5
2022
pubmed:
6
5
2022
medline:
6
5
2022
Statut:
epublish
Résumé
Sensitization to dog is an important risk factor for asthma in children, but the clinical relevance of IgE to available dog- and furry animal allergen molecules is uncertain. Spirometry, methacholine challenge, fraction of exhaled nitric oxide, nasal challenge with dog extract and questionnaires were performed in 59 dog-sensitized children (age 10-18 years). Serum IgE to dog-, cat-, horse extracts and the allergen molecules Can f 1-6, Fel d 1, Fel d 2, Fel d 4 and Equ c 1 were evaluated. Median numbers of positive IgE results to furry animal allergen molecules among children without asthma was 3, with asthma 5.5 and with troublesome asthma 9 (asthma vs. no asthma; Polysensitization to furry animal allergens and lipocalins is associated with asthma in dog-sensitized children. Children with troublesome asthma have higher IgE levels to several dog lipocalins than other dog sensitized children. Polysensitization to furry animal allergens and high IgE levels to the dog lipocalins Can f 2, Can f 4 and Can f 6 is associated with asthma severity in dog dander sensitized children. Molecular allergy diagnostics may thus help the clinicians to evaluate the impact of allergic sensitization on asthma morbidity.
Sections du résumé
Background
UNASSIGNED
Sensitization to dog is an important risk factor for asthma in children, but the clinical relevance of IgE to available dog- and furry animal allergen molecules is uncertain.
Methods
UNASSIGNED
Spirometry, methacholine challenge, fraction of exhaled nitric oxide, nasal challenge with dog extract and questionnaires were performed in 59 dog-sensitized children (age 10-18 years). Serum IgE to dog-, cat-, horse extracts and the allergen molecules Can f 1-6, Fel d 1, Fel d 2, Fel d 4 and Equ c 1 were evaluated.
Results
UNASSIGNED
Median numbers of positive IgE results to furry animal allergen molecules among children without asthma was 3, with asthma 5.5 and with troublesome asthma 9 (asthma vs. no asthma;
Conclusions
UNASSIGNED
Polysensitization to furry animal allergens and lipocalins is associated with asthma in dog-sensitized children. Children with troublesome asthma have higher IgE levels to several dog lipocalins than other dog sensitized children.
Key message
UNASSIGNED
Polysensitization to furry animal allergens and high IgE levels to the dog lipocalins Can f 2, Can f 4 and Can f 6 is associated with asthma severity in dog dander sensitized children. Molecular allergy diagnostics may thus help the clinicians to evaluate the impact of allergic sensitization on asthma morbidity.
Identifiants
pubmed: 35510076
doi: 10.1002/clt2.12149
pii: CLT212149
pmc: PMC9058535
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12149Informations de copyright
© 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
Déclaration de conflit d'intérêts
Ulrika Käck report personal fees from Thermo Fisher Scientific, outside the submitted work. Marianne van Hage report personal fees from Thermo Fisher Scientific, outside the submitted work. Anna Asarnoj report personal fees from Meda/Mylan, Orion Pharma, ALK and Thermo Fisher Scientific outside the submitted work. Jon R. Konradsen has received material from Thermo Fisher to perform the IgE analysis in this project. Hans Grönlund and Gunnar Lilja declare that they have no relevant conflicts of interest.
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