Risk factors associated with the occurrence of total knee arthroplasty in patients with knee osteoarthritis: a nested case-control study.
gender association
knee injuries
nested case–control
osteoarthritis
risk factors
structural changes
symptoms
total knee arthroplasty
Journal
Therapeutic advances in musculoskeletal disease
ISSN: 1759-720X
Titre abrégé: Ther Adv Musculoskelet Dis
Pays: England
ID NLM: 101517322
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
09
2021
accepted:
15
03
2022
entrez:
5
5
2022
pubmed:
6
5
2022
medline:
6
5
2022
Statut:
epublish
Résumé
The aim of this study was to investigate changes over time in osteoarthritis risk factors most closely associated with the occurrence of total knee arthroplasty (TKA). We hypothesize that the robustness of a longitudinal case-control study will provide new information on the association between changes in various clinical and structural parameters in different time frames before TKA. Cases (195; TKA after cohort entry) and controls (468) matched for age, gender, income, WOMAC pain, Kellgren-Lawrence grade and follow-up duration were from the Osteoarthritis Initiative cohort. Associations between changes in sociodemographic, clinical, imaging and osteoarthritis therapies with the occurrence of TKA were performed using conditional logistic regression analyses. Worsening of WOMAC scores (cOR 1.02-1.20, This study provides new information about gender differences in risk factors associated with the occurrence of TKA. Worsening of valgus alignment, cartilage volume loss in the lateral compartment, BMLs and older injuries are important risk factors in women, while medial compartment cartilage loss and meniscal extrusion are in men. The use of pain medication and IASI although associated was found not causal with TKA.
Identifiants
pubmed: 35510169
doi: 10.1177/1759720X221091359
pii: 10.1177_1759720X221091359
pmc: PMC9058358
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1759720X221091359Informations de copyright
© The Author(s), 2022.
Déclaration de conflit d'intérêts
Conflict of interest statement: The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: J-P.P. and J.M-P. are shareholders in ArthroLab Inc. J-P.R. and M.D. are consultants for ArthroLab Inc. P.P. is an employee of ArthroLab Inc. None of the authors are part of the Osteoarthritis Initiative (OAI) investigative team.
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