Spitzoid proliferative nodules arising in a congenital melanocytic naevus: A case report with clinical, dermoscopic and histologic correlation.
congenital melanocytic nevus
melanoma
proliferative nodules
spitz nevus
Journal
The Australasian journal of dermatology
ISSN: 1440-0960
Titre abrégé: Australas J Dermatol
Pays: Australia
ID NLM: 0135232
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
revised:
09
04
2022
received:
11
02
2022
accepted:
15
04
2022
pubmed:
6
5
2022
medline:
17
8
2022
entrez:
5
5
2022
Statut:
ppublish
Résumé
Proliferative nodules (PNs) are benign nodular proliferation of melanocytes occurring within congenital melanocytic naevi (CMN). Differential diagnosis between PN and melanoma is challenging for clinicians and pathologists. We describe the case of a 9-month-old boy who developed multiple nodules arising in a medium-sized CMN. Clinically, pink papules were observed, with dotted vessels on dermoscopy, suggesting spitzoid PN. On histopathological examination, the dermoscopic findings correlated with the vertical vessels of a spitzoid PN. Dermoscopy could be a useful tool to differentiate PN from melanoma. However, further studies describing the dermoscopic features of the different PN subtypes are needed. Histopathology remains the gold standard for definitive diagnosis aided by ancillary molecular tests such as fluorescence in situ hybridization or comparative genomic hybridization.
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e251-e254Informations de copyright
© 2022 The Australasian College of Dermatologists.
Références
van Houten AH, van Dijk MCRF, Schuttelaar MLA. Proliferative nodules in a giant congenital melanocytic nevus-case report and review of the literature. J Cutan Pathol. 2010;37(7):764-76. https://doi.org/10.1111/j.1600-0560.2009.01431.x
Yélamos O, Braun RP, Liopyris K, Wolner ZJ, Kerl K, Gerami P, et al. Dermoscopy and dermatopathology correlates of cutaneous neoplasms. J Am Acad Dermatol. 2019;80(2):341-63. https://doi.org/10.1016/j.jaad.2018.07.073
Krengel S, Scope A, Dusza SW, Vonthein R, Marghoob AA. New recommendations for the categorization of cutaneous features of congenital melanocytic nevi. J Am Acad Dermatol. 2013;68(3):441-51. https://doi.org/10.1016/j.jaad.2012.05.043
Yélamos O, Arva NC, Obregon R, Yazdan P, Wagner A, Guitart J, et al. A comparative study of proliferative nodules and lethal melanomas in congenital nevi from children. Am J Surg Pathol. 2015;39(3):405-15. https://doi.org/10.1097/PAS.0000000000000351
Haliasos EC, Kerner M, Jaimes N, Zalaudek I, Malvehy J, Hofmann-Wellenhof R, et al. Dermoscopy for the pediatric dermatologist part III: dermoscopy of melanocytic lesions. Pediatr Dermatol. 2013;30(3):281-93. https://doi.org/10.1111/pde.12041
Caccavale S, Calabrese G, Mattiello E, Broganelli P, Ramondetta A, Pieretti G, et al. Cutaneous melanoma arising in congenital melanocytic nevus: a retrospective observational study. DRM. 2021;237(3):473-8. https://doi.org/10.1159/000510221
Zalaudek I, Conforti C, Guarneri F, Vezzoni R, Deinlein T, Hofmann-Wellenhof R, et al. Clinical and dermoscopic characteristics of congenital and noncongenital nevus-associated melanomas. J Am Acad Dermatol. 2020;83(4):1080-7. https://doi.org/10.1016/j.jaad.2020.04.120
Scalvenzi M, Palmisano F, Cacciapuoti S, Migliaro F, Siano M, Staibano S, et al. Giant congenital melanocytic naevus with proliferative nodules mimicking congenital malignant melanoma: a case report and review of the literature of congenital melanoma. Case Rep Dermatol Med. 2013;2013:473635. https://doi.org/10.1155/2013/473635
Lambertini M, Baraldi C, Patrizi A, Fanti PA, Corti B, Misciali C, et al. Proliferative melanocytic nodule on small congenital nevus during treatment with etanercept. Am J Dermatopathol. 2018;40(11):871-2. https://doi.org/10.1097/DAD.0000000000001024
Almodovar-Real A, Molina-Leyva A, Aneiros-Fernandez J, Diaz-Martinez MA. Proliferative nodule in melanocytic nevi mimicking deep penetrating nevus. An Bras Dermatol. 2017;92(2):231-3. https://doi.org/10.1590/abd1806-4841.20175383
Del Busto-Wilhelm I, Giavedoni P, Vicente A, et al. Ultrasound findings of proliferative nodule arising in a congenital melanocytic nevus. Melanoma Res. 2020;30(5):528-9. https://doi.org/10.1097/CMR.0000000000000565
Phadke PA, Rakheja D, Le LP, et al. Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases. Am J Surg Pathol. 2011;35(5):656-69. https://doi.org/10.1097/PAS.0b013e31821375ea
Gill P, Prieto VG, Austin MT, Giubellino A, Torres-Cabala CA. Diagnostic utility of PRAME in distinguishing proliferative nodules from melanoma in giant congenital melanocytic nevi. J Cutan Pathol. 2021;48(11):1410-5. https://doi.org/10.1111/cup.14091
Polubothu S, McGuire N, Al-Olabi L, et al. Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi. Br J Dermatol. 2020;182(2):434-43. https://doi.org/10.1111/bjd.18106