Luseogliflozin inhibits high glucose-induced TGF-
Animals
Cardiomegaly
/ pathology
Diabetes Mellitus
/ metabolism
Glucose
/ metabolism
Humans
Male
Mice
Myocytes, Cardiac
/ metabolism
RNA, Messenger
/ genetics
Sodium-Glucose Transporter 2
/ metabolism
Sodium-Hydrogen Exchanger 1
/ metabolism
Sorbitol
/ analogs & derivatives
Transforming Growth Factor beta2
/ metabolism
Cariporide
diabetic cardiomyopathy
fibrosis
luseogliflozin
sodium-glucose cotransporter-2 inhibitor
sodium-hydrogen exchanger-1
transforming growth factor-β2
Journal
The Journal of international medical research
ISSN: 1473-2300
Titre abrégé: J Int Med Res
Pays: England
ID NLM: 0346411
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
entrez:
5
5
2022
pubmed:
6
5
2022
medline:
7
5
2022
Statut:
ppublish
Résumé
Sodium-glucose cotransporter-2 (SGLT2) inhibitors exhibit cardioprotective properties in patients with diabetes. However, SGLT2 is not expressed in the heart, and the underlying molecular mechanisms are not fully understood. We investigated whether the SGLT2 inhibitor luseogliflozin exerts beneficial effects on high glucose-exposed cardiomyocytes via the suppression of sodium-hydrogen exchanger-1 (NHE-1) activity. Mouse cardiomyocytes were incubated under normal or high glucose conditions with vehicle, luseogliflozin, or the NHE-1 inhibitor cariporide. NHE-1 activity and gene expression were evaluated by the SNARF assay and real-time reverse transcription-polymerase chain reaction (RT-PCR) analysis, respectively. Six-week-old male db/db mice were treated with vehicle or luseogliflozin for 6 weeks, and the hearts were collected for histological, RT-PCR, and western blot analyses. High glucose increased NHE-1 activity and transforming growth factor Luseogliflozin may suppress cardiac hypertrophy in diabetes by reducing
Identifiants
pubmed: 35510669
doi: 10.1177/03000605221097490
pmc: PMC9082751
doi:
Substances chimiques
RNA, Messenger
0
Slc9a1 protein, mouse
0
Sodium-Glucose Transporter 2
0
Sodium-Hydrogen Exchanger 1
0
Transforming Growth Factor beta2
0
Sorbitol
506T60A25R
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol
C596HWF74Z
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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