Genetic correlation between thyroid hormones and Parkinson's disease.
Parkinson’s disease
SNPs
immune pathogenesis
risk genes
thyroid hormones
Journal
Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202
Informations de publication
Date de publication:
23 06 2022
23 06 2022
Historique:
received:
15
03
2022
accepted:
29
04
2022
pubmed:
6
5
2022
medline:
28
6
2022
entrez:
5
5
2022
Statut:
ppublish
Résumé
Parkinson's disease (PD) was reported to be connected with thyroid diseases clinically, which might be a critical clew to immune pathogenesis of PD. However, there was no further research to study the pathogenesis correlation between PD and thyroid diseases. In this study, except for investigating the difference in thyroid hormone between PD and the control group, we explored genetic correlation between thyroid and PD. We tried to find their shared molecular pathway by analyzing the effect of PD risk genes on thyroid function. Interestingly, most of those 12 meaningful SNPs we found could affect PD and thyroid function through immune mechanism, which is consistent with our original conjecture and provides significant evidence for the immune pathogenesis of PD.
Identifiants
pubmed: 35511827
pii: 6578682
doi: 10.1093/cei/uxac044
pmc: PMC9226140
doi:
Substances chimiques
Thyroid Hormones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
372-379Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Immunology.
Références
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1439-44
pubmed: 21220347
Neurosci Lett. 2013 Mar 14;537:1-5
pubmed: 23340200
Neurodegener Dis. 2012;10(1-4):277-84
pubmed: 22205172
Cell. 2016 Jul 14;166(2):314-327
pubmed: 27345367
Cancers (Basel). 2020 Dec 23;13(1):
pubmed: 33374707
J Endocrinol Invest. 2021 Jan;44(1):1-13
pubmed: 32500445
Nat Rev Neurol. 2020 Jun;16(6):303-318
pubmed: 32332985
J Neurol. 2015 Jul;262(7):1762-8
pubmed: 25987207
Cell Death Differ. 2012 Oct;19(10):1623-33
pubmed: 22539006
Biochem Soc Trans. 2019 Apr 30;47(2):651-661
pubmed: 30837320
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
Oncol Lett. 2017 Oct;14(4):4599-4604
pubmed: 28943960
Parkinsonism Relat Disord. 2020 May;74:28-32
pubmed: 32294589
Neuroscience. 2015 Aug 27;302:74-88
pubmed: 25284317
FEBS J. 2015 Jun;282(11):2076-88
pubmed: 25712550
Endocr Connect. 2020 Aug;9(8):783-792
pubmed: 32688342
Int J Mol Sci. 2013 Jun 27;14(7):13433-46
pubmed: 23807503
Mol Neurodegener. 2014 Nov 12;9:47
pubmed: 25391693
Int J Oncol. 2019 Jul;55(1):21-34
pubmed: 31180559
Brain Pathol. 2009 Jan;19(1):91-107
pubmed: 18462474
Pharmacol Rev. 2020 Apr;72(2):466-485
pubmed: 32144120
Carcinogenesis. 2015 Nov;36(11):1407-18
pubmed: 26354775
ACS Chem Neurosci. 2019 Feb 20;10(2):792-802
pubmed: 30400738
Neuroscience. 2001;105(4):891-8
pubmed: 11530227
Nat Genet. 2014 Sep;46(9):989-93
pubmed: 25064009
J Biol Chem. 2005 Nov 11;280(45):37599-609
pubmed: 16157584
Hum Immunol. 2016 Oct;77(10):944-951
pubmed: 27458112
CNS Neurosci Ther. 2019 Apr;25(4):422-429
pubmed: 30676692
Sci Rep. 2019 Sep 20;9(1):13659
pubmed: 31541140
Toxicol Sci. 2016 Feb;149(2):300-11
pubmed: 26519956
Autoimmun Rev. 2016 Oct;15(10):1005-11
pubmed: 27497913