The Mettl3 epitranscriptomic writer amplifies p53 stress responses.

Animals Carcinogenesis Methyltransferases / metabolism Mice RNA Transcription Factors / metabolism Tumor Suppressor Protein p53 / genetics
DNA damage METTL14 METTL3 N(6)-methyladenosine (m6A) modification epitranscriptomics lung cancer mass spectrometry methyltransferase complex p53 tumor suppressor

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
07 07 2022
Historique:
received: 23 03 2021
revised: 05 01 2022
accepted: 06 04 2022
pubmed: 6 5 2022
medline: 14 7 2022
entrez: 5 5 2022
Statut: ppublish

Résumé

The p53 transcription factor drives anti-proliferative gene expression programs in response to diverse stressors, including DNA damage and oncogenic signaling. Here, we seek to uncover new mechanisms through which p53 regulates gene expression using tandem affinity purification/mass spectrometry to identify p53-interacting proteins. This approach identified METTL3, an m

Identifiants

DOI: 10.1016/j.molcel.2022.04.010 PMID: 35512709 PMC: PMC9807187
pubmed: 35512709
pii: S1097-2765(22)00321-5
doi: 10.1016/j.molcel.2022.04.010
pmc: PMC9807187
mid: NIHMS1860204
pii:
doi:

Substances chimiques

Transcription Factors 0
Tumor Suppressor Protein p53 0
RNA 63231-63-0
Methyltransferases EC 2.1.1.-
Mettl3 protein, mouse EC 2.1.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2370-2384.e10

Subventions

Organisme : NCI NIH HHS
ID : R01 CA234605
Pays : United States
Organisme : NCI NIH HHS
ID : DP1 CA238296
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA127724
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD086634
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197591
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA095441
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA250534
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests H.Y.C. is a co-founder of Accent Therapeutics, Boundless Bio, and an advisor of 10x Genomics, Arsenal Biosciences, and Spring Discovery. H.Y.C. is an advisory board member of Molecular Cell. C.C. is an advisor and equity holder of GRAIL/Illumina, Ravel Biotechnology, and DeepCell, and an advisor to NanoString and Genentech. The remaining authors declare no competing interests.

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Auteurs

Nitin Raj (N)

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Mengxiong Wang (M)

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Jose A Seoane (JA)

Vall d'Hebron Institute of Oncology (VHIO), Barcelona 08035, Spain.

Richard L Zhao (RL)

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Alyssa M Kaiser (AM)

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Nancie A Moonie (NA)

Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Janos Demeter (J)

Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Anthony M Boutelle (AM)

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Craig H Kerr (CH)

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abigail S Mulligan (AS)

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Clare Moffatt (C)

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Shelya X Zeng (SX)

Department of Biochemistry & Molecular Biology, Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USA; Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Hua Lu (H)

Department of Biochemistry & Molecular Biology, Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USA; Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Maria Barna (M)

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Christina Curtis (C)

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Howard Y Chang (HY)

Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94304, USA.

Peter K Jackson (PK)

Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Laura D Attardi (LD)

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: attardi@stanford.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Mettl3 epitranscriptomic writer amplifies...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › The Mettl3 epitranscriptomic writer amplifies...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › The Mettl3 epitranscriptomic writer amplifies...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The Mettl3 epitranscriptomic writer amplifies...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › The Mettl3 epitranscriptomic writer amplifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › The Mettl3 epitranscriptomic writer amplifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › The Mettl3 epitranscriptomic writer amplifies...