Harnessing the liver to induce antigen-specific immune tolerance.
Antigen presentation
Autoimmune disease
Immune tolerance
Immunotherapy
Nanomedicine
Scavenger cells
Journal
Seminars in immunopathology
ISSN: 1863-2300
Titre abrégé: Semin Immunopathol
Pays: Germany
ID NLM: 101308769
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
16
02
2022
accepted:
20
04
2022
pubmed:
6
5
2022
medline:
8
7
2022
entrez:
5
5
2022
Statut:
ppublish
Résumé
Autoimmune diseases develop when the adaptive immune system attacks the body's own antigens leading to tissue damage. At least 80 different conditions are believed to have an autoimmune aetiology, including rheumatoid arthritis, type I diabetes, multiple sclerosis or systemic lupus erythematosus. Collectively, autoimmune diseases are a leading cause of severe health impairment along with substantial socioeconomic costs. Current treatments are mostly symptomatic and non-specific, and it is typically not possible to cure these diseases. Thus, the development of more causative treatments that suppress only the pathogenic immune responses, but spare general immunity is of great biomedical interest. The liver offers considerable potential for development of such antigen-specific immunotherapies, as it has a distinct physiological capacity to induce immune tolerance. Indeed, the liver has been shown to specifically suppress autoimmune responses to organ allografts co-transplanted with the liver or to autoantigens that were transferred to the liver. Liver tolerance is established by a unique microenvironment that facilitates interactions between liver-resident antigen-presenting cells and lymphocytes passing by in the low blood flow within the hepatic sinusoids. Here, we summarise current concepts and mechanisms of liver immune tolerance, and review present approaches to harness liver tolerance for antigen-specific immunotherapy.
Identifiants
pubmed: 35513495
doi: 10.1007/s00281-022-00942-8
pii: 10.1007/s00281-022-00942-8
pmc: PMC9256566
doi:
Substances chimiques
Autoantigens
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
475-484Informations de copyright
© 2022. The Author(s).
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