CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk.
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
24
03
2021
accepted:
21
03
2022
pubmed:
6
5
2022
medline:
20
5
2022
entrez:
5
5
2022
Statut:
ppublish
Résumé
Chronic lymphoproliferative disorder of natural killer cells (CLPD-NK) is characterized by clonal expansion of natural killer (NK) cells where the underlying genetic mechanisms are incompletely understood. In the present study, we report somatic mutations in the chemokine gene CCL22 as the hallmark of a distinct subset of CLPD-NK. CCL22 mutations were enriched at highly conserved residues, mutually exclusive of STAT3 mutations and associated with gene expression programs that resembled normal CD16
Identifiants
pubmed: 35513723
doi: 10.1038/s41588-022-01059-2
pii: 10.1038/s41588-022-01059-2
pmc: PMC9117519
mid: NIHMS1791505
doi:
Substances chimiques
Ccl22 protein, mouse
0
Chemokine CCL22
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
637-648Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM007267
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197695
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA189859
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA196172
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA044579
Pays : United States
Organisme : NLM NIH HHS
ID : T32 LM012416
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA232760
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA178393
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA196040
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136314
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180820
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM080202
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
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