Design and formulation of polymeric nanosponge tablets with enhanced solubility for combination therapy.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
16 Sep 2020
16 Sep 2020
Historique:
received:
30
07
2020
accepted:
06
09
2020
entrez:
6
5
2022
pubmed:
21
9
2020
medline:
21
9
2020
Statut:
epublish
Résumé
Three drugs namely caffeine, paracetamol, and aceclofenac are commonly used for treating various acute and chronic pain related ailments. These 3 drugs have varied solubility profiles, and formulating them into a single tablet did not have the desired dissolution profile for drug absorption. The objective of the present research was to tailor the drug release profile by altering drug solubility. This was achieved by loading the drug into nanosponges. Here, three-dimensional colloidal nanosponges were prepared using β-cyclodextrin with dimethyl carbonate as a cross-linker using the hot-melt compression method. The prepared nanosponges were characterized by FTIR,
Identifiants
pubmed: 35514416
doi: 10.1039/d0ra06611g
pii: d0ra06611g
pmc: PMC9056836
doi:
Types de publication
Journal Article
Langues
eng
Pagination
34869-34884Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to declare.
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