Hemodynamic Changes During Physiological and Pharmacological Stress Testing in Patients With Heart Failure: A Systematic Review and Meta-Analysis.
HFpEF—heart failure with preserved ejection fraction
HFrEF—heart failure with reduced ejection fraction
exercise testing (in) heart failure
heart failure
meta-analysis
physiologic changes
stress testing
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
31
05
2021
accepted:
24
02
2022
entrez:
6
5
2022
pubmed:
7
5
2022
medline:
7
5
2022
Statut:
epublish
Résumé
Although disease etiologies differ, heart failure patients with preserved and reduced ejection fraction (HFpEF and HFrEF, respectively) both present with clinical symptoms when under stress and impaired exercise capacity. The extent to which the adaptation of heart rate (HR), stroke volume (SV), and cardiac output (CO) under stress conditions is altered can be quantified by stress testing in conjunction with imaging methods and may help to detect the diminishment in a patient's condition early. The aim of this meta-analysis was to quantify hemodynamic changes during physiological and pharmacological stress testing in patients with HF. A systematic literature search (PROSPERO 2020:CRD42020161212) in MEDLINE was conducted to assess hemodynamic changes under dynamic and pharmacological stress testing at different stress intensities in HFpEF and HFrEF patients. Pooled mean changes were estimated using a random effects model. Altogether, 140 study arms with 7,248 exercise tests were analyzed. High-intensity dynamic stress testing represented 73% of these data (70 study arms with 5,318 exercise tests), where: HR increased by 45.69 bpm (95% CI 44.51-46.88; [https://www.crd.york.ac.uk/prospero/], identifier [CRD42020161212].
Identifiants
pubmed: 35514442
doi: 10.3389/fcvm.2022.718114
pmc: PMC9062977
doi:
Types de publication
Systematic Review
Langues
eng
Pagination
718114Informations de copyright
Copyright © 2022 Bingel, Messroghli, Weimar, Runte, Salcher-Konrad, Kelle, Pieske, Berger, Kuehne, Goubergrits, Fuerstenau and Kelm.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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