Reassessing the interpretation of oxidation-reduction potential in male infertility.
DNA integrity
male infertility
oxidoreduction potential
sperm
Journal
Reproduction & fertility
ISSN: 2633-8386
Titre abrégé: Reprod Fertil
Pays: England
ID NLM: 101778727
Informations de publication
Date de publication:
01 04 2022
01 04 2022
Historique:
received:
23
02
2022
accepted:
18
03
2022
entrez:
6
5
2022
pubmed:
7
5
2022
medline:
7
5
2022
Statut:
epublish
Résumé
Male Infertility Oxidative System (MiOXSYS) has been proposed as a rapid and promising technology for the evaluation of sperm oxidative stress. In this case-control study, 134 men with normal sperm parameters (NSP) and 574 men with abnormal sperm parameters (ASP), according to the World Health Organization sperm assessment references values established in 2010, were enrolled. Conventional sperm parameters were evaluated in all patients. Sperm static oxido-reduction potential (sORP) was assessed using the MiOXSYS. Sperm DNA integrity was measured in 604 patients. To ensure that sperm concentration was not a confounding factor in the sORP index ratio, sperm and seminal fluid sORP from 57 randomly selected additional patients were also measured using the MiOXSYS. sORP index (mV/10 The World Health Organization (WHO) has recognized that oxidative stress may have a role in male infertility. Oxidative stress happens when there is an imbalance between the production of molecules containing oxygen and the antioxidants, molecules that neutralize the molecules containing oxygen. The molecules containing oxygen can cause damage to sperm DNA. This damage can be measured using a particular index and this study looked at whether the concentration of the sperm sample might have an impact on results and suggests this should be taken into consideration by clinicians and researchers.
Identifiants
pubmed: 35514536
doi: 10.1530/RAF-21-0005
pii: RAF-21-0005
pmc: PMC9066566
doi:
Substances chimiques
DNA
9007-49-2
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Pagination
67-76Informations de copyright
© The authors.
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