Rationale and design of a screening study to detect schistosomiasis-associated pulmonary hypertension in Ethiopia and Zambia.
pulmonary hypertension
schistosomiasis
study design
Journal
Pulmonary circulation
ISSN: 2045-8932
Titre abrégé: Pulm Circ
Pays: United States
ID NLM: 101557243
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
24
11
2021
revised:
28
01
2022
accepted:
27
03
2022
entrez:
6
5
2022
pubmed:
7
5
2022
medline:
7
5
2022
Statut:
epublish
Résumé
Schistosomiasis is a major cause of pulmonary arterial hypertension (PAH) worldwide, but the prevalence and risk factors for schistosomiasis-associated PAH (SchPAH) development are not well understood. Schistosomiasis-associated hepatosplenic disease (SchHSD) is thought to be a major risk factor for PAH development. Herein, we describe our plans for prospectively screening SchHSD subjects for clinical evidence of PAH at two major academic medical centers and national referral hospitals in Addis Ababa, Ethiopia and Lusaka, Zambia. The screening study will primarily be conducted by echocardiography, in addition to clinical assessments. Plasma samples will be drawn and banked for subsequent analysis based on preclinical animal model rationale. If successful, this study will demonstrate feasibility of conducting prospective cohort studies of SchPAH screening in schistosomiasis-endemic regions of Africa, and provide initial data on clinic-based disease prevalence and potential mechanistic biomarkers underlying disease pathogenesis.
Identifiants
pubmed: 35514775
doi: 10.1002/pul2.12072
pii: PUL212072
pmc: PMC9063961
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12072Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL152961
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135872
Pays : United States
Informations de copyright
© 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Infect Dis Poverty. 2017 Mar 22;6(1):63
pubmed: 28327187
Eur Heart J. 2016 Jan 1;37(1):67-119
pubmed: 26320113
Infect Dis Poverty. 2018 Apr 30;7(1):41
pubmed: 29706131
Trop Med Int Health. 2012 Jan;17(1):112-8
pubmed: 21951396
Echocardiography. 2015 Jan;32(1):10-8
pubmed: 24661140
Int J Clin Pract Suppl. 2011 Jan;(169):8-10
pubmed: 21176010
Pulm Circ. 2021 Oct 21;11(4):20458940211054304
pubmed: 34707859
Life Sci. 2014 Aug 28;111(1-2):12-7
pubmed: 25064826
Mem Inst Oswaldo Cruz. 2006 Sep;101 Suppl 1:79-85
pubmed: 17308751
Eur Respir J. 2014 Dec;44(6):1428-46
pubmed: 25359355
Circulation. 2009 Mar 24;119(11):1518-23
pubmed: 19273723
Circ Cardiovasc Imaging. 2012 Sep 1;5(5):628-36
pubmed: 22875884
Eur Respir J. 2022 Aug 4;60(2):
pubmed: 34996833
Immunol Cell Biol. 2007 Feb-Mar;85(2):148-54
pubmed: 17160074
Chest. 2004 Jul;126(1 Suppl):14S-34S
pubmed: 15249493
Korean Circ J. 2015 Sep;45(5):362-3
pubmed: 26413102
Ethiop Med J. 2017;55(Suppl 1):75-80
pubmed: 28878432
Front Immunol. 2021 Mar 12;12:635869
pubmed: 33790908
Eur Respir Rev. 2009 Mar;18(111):13-7
pubmed: 20956117
Braz J Infect Dis. 2015 Mar-Apr;19(2):196-205
pubmed: 25636189
Int J Cardiovasc Imaging. 2021 Sep;37(9):2637-2645
pubmed: 34146206
Front Immunol. 2020 Dec 10;11:608883
pubmed: 33362796
Pulm Circ. 2014 Dec;4(4):596-611
pubmed: 25610596
Eur Respir J. 2019 Jan 24;53(1):
pubmed: 30545968
Clin Med (Lond). 2015 Feb;15(1):67-9
pubmed: 25650202
PLoS One. 2017 Dec 11;12(12):e0189400
pubmed: 29228024
Clin Med Insights Cardiol. 2015 Jul 05;9:65-75
pubmed: 26244034
Korean Circ J. 2015 Sep;45(5):398-407
pubmed: 26413108
Parasitol Res. 2020 Jan;119(1):1-10
pubmed: 31773307
Eur Respir J. 2017 Aug 3;50(2):
pubmed: 28775047
Acta Psychiatr Scand Suppl. 1999;397:84-91
pubmed: 10470360
N Engl J Med. 2019 Dec 26;381(26):2519-2528
pubmed: 31881138
Pulm Circ. 2022 Apr 22;12(2):e12072
pubmed: 35514775
Nat Rev Microbiol. 2004 Jan;2(1):12-3
pubmed: 15035004
Acta Trop. 2000 Oct 23;77(1):41-51
pubmed: 10996119
Nat Rev Dis Primers. 2018 Aug 9;4(1):13
pubmed: 30093684
Lancet. 2006 Sep 23;368(9541):1106-18
pubmed: 16997665
Lancet Infect Dis. 2006 Jul;6(7):411-25
pubmed: 16790382
Am J Trop Med Hyg. 2017 Nov;97(5):1603-1610
pubmed: 29140241
Chest. 2021 Jan;159(1):337-346
pubmed: 32882243
Lancet. 2018 Jan 27;391(10118):307-308
pubmed: 29413041
Glob Cardiol Sci Pract. 2020 Apr 30;2020(1):e202005
pubmed: 33150150
Chest. 2015 Feb;147(2):495-501
pubmed: 25317567
Eur Respir J. 2019 Jun 5;53(6):
pubmed: 30923187
Heart. 2011 Apr;97(8):612-22
pubmed: 21357375
Chest. 2019 Aug;156(2):323-337
pubmed: 30772387