Neutralizing Dromedary-Derived Nanobodies Against BotI-Like Toxin From the Most Hazardous Scorpion Venom in the Middle East and North Africa Region.

Animals Camelus Mice Scorpion Stings / therapy Scorpion Venoms Scorpions Single-Domain Antibodies / therapeutic use
Buthus occitanus tunetanus VHH Dromedary library nanobodies neutralizing capacity phage display scorpion toxin

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 28 01 2022
accepted: 16 03 2022
entrez: 6 5 2022
pubmed: 7 5 2022
medline: 10 5 2022
Statut: epublish

Résumé

Scorpion envenoming is a severe health problem in many regions causing significant clinical toxic effects and fatalities. In the Middle East/North Africa (MENA) region,

Identifiants

DOI: 10.3389/fimmu.2022.863012 PMID: 35514999 PMC: PMC9063451
pubmed: 35514999
doi: 10.3389/fimmu.2022.863012
pmc: PMC9063451
doi:

Substances chimiques

Scorpion Venoms 0
Single-Domain Antibodies 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

863012

Informations de copyright

Copyright © 2022 Ben Abderrazek, Ksouri, Idoudi, Dhaouadi, Hamdi, Vincke, Farah, Benlasfar, Majdoub, El Ayeb, Muyldermans and Bouhaouala-Zahar.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Rahma Ben Abderrazek (R)

Laboratoire des Biomolécules, Venins et Applications Théranostiques, Institut Pasteur Tunis, University Tunis El Manar, Tunis, Tunisia.

Ayoub Ksouri (A)

Laboratoire des Biomolécules, Venins et Applications Théranostiques, Institut Pasteur Tunis, University Tunis El Manar, Tunis, Tunisia.

Faten Idoudi (F)

Laboratoire des Biomolécules, Venins et Applications Théranostiques, Institut Pasteur Tunis, University Tunis El Manar, Tunis, Tunisia.

Sayda Dhaouadi (S)

Laboratoire des Biomolécules, Venins et Applications Théranostiques, Institut Pasteur Tunis, University Tunis El Manar, Tunis, Tunisia.

Emna Hamdi (E)

Laboratoire des Biomolécules, Venins et Applications Théranostiques, Institut Pasteur Tunis, University Tunis El Manar, Tunis, Tunisia.

Cécile Vincke (C)

Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Myeloid Cell Immunology Lab, Vlaams Interuniversitair Instituut voor Biotechnologie (VIB) Center for Inflammation Research, Brussels, Belgium.

Azer Farah (A)

Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.

Zakaria Benlasfar (Z)

Laboratoire des Biomolécules, Venins et Applications Théranostiques, Institut Pasteur Tunis, University Tunis El Manar, Tunis, Tunisia.

Hafedh Majdoub (H)

Unité des Services Communs de Recherche (USCR) Séquenceur de Protéines, Faculté des Sciences de Sfax, Sfax, Tunisia.

Mohamed El Ayeb (M)

Laboratoire des Biomolécules, Venins et Applications Théranostiques, Institut Pasteur Tunis, University Tunis El Manar, Tunis, Tunisia.

Serge Muyldermans (S)

Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.

Balkiss Bouhaouala-Zahar (B)

Laboratoire des Biomolécules, Venins et Applications Théranostiques, Institut Pasteur Tunis, University Tunis El Manar, Tunis, Tunisia.
Unité des Services Communs de Recherche (USCR) Séquenceur de Protéines, Faculté des Sciences de Sfax, Sfax, Tunisia.
Faculté de Médecine de Tunis, Université Tunis El Manar, Tunis, Tunisia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Neutralizing Dromedary-Derived Nanobodies...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Camelidae › Chameaux › Neutralizing Dromedary-Derived Nanobodies...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Neutralizing Dromedary-Derived Nanobodies...
questionsmedicales.fr › Plaies et blessures › Morsures et piqûres › Piqûres de scorpions › Neutralizing Dromedary-Derived Nanobodies...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins d'arthropode › Venins de scorpion › Neutralizing Dromedary-Derived Nanobodies...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Arachnida › Scorpions › Neutralizing Dromedary-Derived Nanobodies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Fragments d'immunoglobuline › Fragments Fab d'immunoglobuline › Anticorps à domaine unique › Neutralizing Dromedary-Derived Nanobodies...