Cisplatin, glutathione and the third wheel: a copper-(1,10-phenanthroline) complex modulates cisplatin-GSH interactions from antagonism to synergism in cancer cells resistant to cisplatin.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
11 Feb 2019
11 Feb 2019
Historique:
received:
23
11
2018
accepted:
01
02
2019
entrez:
6
5
2022
pubmed:
12
2
2019
medline:
12
2
2019
Statut:
epublish
Résumé
The antagonistic effect of glutathione (GSH) against the cytotoxicity of cisplatin was observed in both wild type and cisplatin-resistant human leukaemia and ovarian carcinoma cell lines. The simultaneous presence of the cytotoxic copper complex [Cu(phen)
Identifiants
pubmed: 35515894
doi: 10.1039/c8ra09652j
pii: c8ra09652j
pmc: PMC9060805
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5362-5376Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts of interest to declare.
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