Chemoenzymatic Synthesis of Original Stilbene Dimers Possessing Wnt Inhibition Activity in Triple-Negative Breast Cancer Cells Using the Enzymatic Secretome of
Botrytis cinerea
Wnt inhibition
chemoenzymatic synthesis
dry load introduction
enzymatic secretome
high-resolution semi-preparative HPLC
stilbene dimers
triple negative breast cancer cells
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
02
2022
accepted:
18
03
2022
entrez:
6
5
2022
pubmed:
7
5
2022
medline:
7
5
2022
Statut:
epublish
Résumé
The Wnt signaling pathway controls multiple events during embryonic development of multicellular animals and is carcinogenic when aberrantly activated in adults. Breast cancer and triple-negative breast cancer (TNBC) in particular depend upon Wnt pathway overactivation. Despite this importance, no Wnt pathway-targeting drugs are currently available, which necessitates novel approaches to search for therapeutically relevant compounds targeting this oncogenic pathway. Stilbene analogs represent an under-explored field of therapeutic natural products research. In the present work, a library of complex stilbene derivatives was obtained through biotransformation of a mixture of resveratrol and pterostilbene using the enzymatic secretome of
Identifiants
pubmed: 35518712
doi: 10.3389/fchem.2022.881298
pii: 881298
pmc: PMC9062038
doi:
Types de publication
Journal Article
Langues
eng
Pagination
881298Informations de copyright
Copyright © 2022 Huber, Koval, Marcourt, Héritier, Schnee, Michellod, Scapozza, Katanaev, Wolfender, Gindro and Ferreira Queiroz.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cancer Lett. 2019 May 1;449:45-55
pubmed: 30771433
Exp Ther Med. 2019 Mar;17(3):2242-2246
pubmed: 30867708
Experientia. 1977 Feb 15;33(2):151-2
pubmed: 844529
Clin Breast Cancer. 2009 Feb;9(1):29-33
pubmed: 19299237
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11717-22
pubmed: 22753465
Cancer. 2004 Jan 1;100(1):44-52
pubmed: 14692023
NPJ Breast Cancer. 2021 May 20;7(1):56
pubmed: 34016991
Am J Transl Res. 2012;4(1):44-51
pubmed: 22347521
Anticancer Agents Med Chem. 2021 Oct 28;21(16):2117-2129
pubmed: 33390126
Biochem Pharmacol. 2009 Feb 1;77(3):337-47
pubmed: 19038233
Cells. 2020 Mar 02;9(3):
pubmed: 32131438
J Chromatogr A. 2019 Aug 2;1598:85-91
pubmed: 30926257
PLoS One. 2014 Jun 04;9(6):e98861
pubmed: 24897117
Nature. 2001 Jan 11;409(6817):241-6
pubmed: 11196652
Nat Prod Rep. 2009 Jul;26(7):916-35
pubmed: 19554241
Cancer Lett. 2021 Sep 1;515:63-72
pubmed: 34052324
Antioxidants (Basel). 2021 Mar 21;10(3):
pubmed: 33801098
Clin Transl Med. 2013 Jan 17;2(1):3
pubmed: 23369605
Biochem Pharmacol. 2011 Nov 15;82(10):1311-9
pubmed: 21689640
Nat Commun. 2016 Feb 04;7:10633
pubmed: 26843124
J Nat Prod. 2020 Mar 27;83(3):770-803
pubmed: 32162523
J Mol Graph Model. 2010 Sep;29(2):157-70
pubmed: 20579912
Eur J Med Chem. 2021 Oct 15;222:113562
pubmed: 34116325
J Nat Prod. 2020 Aug 28;83(8):2347-2356
pubmed: 32705864
J Cell Physiol. 2020 May;235(5):4135-4145
pubmed: 31637721
BMC Cancer. 2013 Nov 10;13:537
pubmed: 24209998
Pathobiology. 2006;73(5):213-23
pubmed: 17314492
Nat Rev Clin Oncol. 2022 Feb;19(2):91-113
pubmed: 34754128
Front Oncol. 2020 Dec 10;10:602817
pubmed: 33363033
Chem Rev. 2015 Sep 9;115(17):8976-9027
pubmed: 25835567
J Chem Theory Comput. 2021 Jul 13;17(7):4291-4300
pubmed: 34096718
Mol Cell Ther. 2014 Sep 11;2:28
pubmed: 26056595
Biochem Pharmacol. 2014 Feb 15;87(4):571-8
pubmed: 24355563
Front Plant Sci. 2022 Jan 13;12:805610
pubmed: 35095976
Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S52-61
pubmed: 18504708
EMBO Mol Med. 2013 Feb;5(2):264-79
pubmed: 23307470
Pharmacol Ther. 2015 Feb;146:1-11
pubmed: 25172549
Cancer Lett. 2018 Oct 28;435:110-120
pubmed: 30098400
Eur J Pharm Biopharm. 2008 Feb;68(2):430-40
pubmed: 17703929
Am J Pathol. 2010 Jun;176(6):2911-20
pubmed: 20395444
Front Plant Sci. 2019 Oct 25;10:1329
pubmed: 31708947
Eur J Pharm Biopharm. 2007 Jun;66(3):475-82
pubmed: 17267188
Oncogene. 2011 Oct 27;30(43):4437-46
pubmed: 21532620
Curr Biol. 2003 Apr 15;13(8):680-5
pubmed: 12699626
Ann Pharmacother. 2021 Jul;55(7):921-931
pubmed: 33070624
Oncologist. 2021 Aug;26(8):635-639
pubmed: 33559918
Nature. 2014 Sep 25;513(7519):481-3
pubmed: 25254460
Methods Cell Biol. 2019;149:57-75
pubmed: 30616827
J Clin Pathol. 2013 Jun;66(6):530-42
pubmed: 23436929
Drug Discov Today. 2022 Mar;27(3):777-792
pubmed: 34915171
Handb Exp Pharmacol. 2021;269:215-248
pubmed: 34455487
Nat Rev Drug Discov. 2006 Dec;5(12):997-1014
pubmed: 17139285
BBA Clin. 2015 Mar 12;3:257-75
pubmed: 26676166
J Nat Prod. 2017 Apr 28;80(4):887-898
pubmed: 28332842
J Agric Food Chem. 2011 Aug 10;59(15):8180-6
pubmed: 21726087
Planta Med. 2005 Oct;71(10):973-6
pubmed: 16254835
BMC Cancer. 2014 Feb 24;14:124
pubmed: 24564888
Sci Rep. 2018 May 9;8(1):7329
pubmed: 29743726
Sci Rep. 2015 Jul 23;5:12465
pubmed: 26202299