Diastereoselective approach to rationally design tetrahydro-β-carboline-isatin conjugates as potential SERMs against breast cancer.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
22 Mar 2019
22 Mar 2019
Historique:
received:
28
01
2019
accepted:
11
03
2019
entrez:
6
5
2022
pubmed:
28
3
2019
medline:
28
3
2019
Statut:
epublish
Résumé
A series of tetrahydro-β-carboline-isatin conjugates, with varying substituents as well as stereochemistry at C-1 and C-5 position of tetrahydro-β-carboline (THβC) and isatin ring, were prepared and assayed for anti-proliferative efficacy on Estrogen Responsive ER(+) (MCF-7) and ER(-ve) MDA-MB-231 cell-lines. The synthesized scaffolds displayed selective anti-proliferative efficacy against MCF-7 cell-line with the most active conjugate 8b exhibiting an IC
Identifiants
pubmed: 35520746
doi: 10.1039/c9ra00744j
pii: c9ra00744j
pmc: PMC9062147
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9809-9819Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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