Neutrophil phenotypes and functions in cancer: A consensus statement.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
06 06 2022
06 06 2022
Historique:
received:
23
12
2021
revised:
11
03
2022
accepted:
23
03
2022
entrez:
6
5
2022
pubmed:
7
5
2022
medline:
11
5
2022
Statut:
ppublish
Résumé
Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.
Identifiants
pubmed: 35522219
pii: 213202
doi: 10.1084/jem.20220011
pmc: PMC9086501
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01 CA218579
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA187392
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35GM118337
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA085862
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG070682
Pays : United States
Organisme : Wellcome Trust
ID : 209422/Z/17/Z
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM129633
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Swiss National Science Foundation
ID : 310030_179324
Pays : Switzerland
Organisme : NIAMS NIH HHS
ID : AR065959-01
Pays : United States
Organisme : Cancer Research UK
ID : FC001112
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001112
Pays : United Kingdom
Organisme : European Research Council
ID : ERC CoG-H2020-725492
Pays : International
Organisme : NIAMS NIH HHS
ID : R01 AR076242
Pays : United States
Organisme : Medical Research Council
ID : MR/R02149x/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R35 HL135765
Pays : United States
Informations de copyright
© 2022 Quail et al.
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