Airway Macrophages Encompass Transcriptionally and Functionally Distinct Subsets Altered by Smoking.
COPD
airway macrophages
lung
single-cell and bulk RNA-seq
smoking
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
pubmed:
7
5
2022
medline:
4
8
2022
entrez:
6
5
2022
Statut:
ppublish
Résumé
Alveolar macrophages (AMs) are functionally important innate cells involved in lung homeostasis and immunity and whose diversity in health and disease is a subject of intense investigations. Yet, it remains unclear to what extent conditions like smoking or chronic obstructive pulmonary disease (COPD) trigger changes in the AM compartment. Here, we aimed to explore heterogeneity of human AMs isolated from healthy nonsmokers, smokers without COPD, and smokers with COPD by analyzing BAL fluid cells by flow cytometry and bulk and single-cell RNA sequencing. We found that subpopulations of BAL fluid CD206
Identifiants
pubmed: 35522264
doi: 10.1165/rcmb.2021-0563OC
pmc: PMC9348561
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
241-252Commentaires et corrections
Type : CommentIn
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