Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment.
Cerebral blood flow
Cognition
Dementia
Flow-mediated dilation
Pulsatility index
Pulse wave velocity
Journal
European journal of applied physiology
ISSN: 1439-6327
Titre abrégé: Eur J Appl Physiol
Pays: Germany
ID NLM: 100954790
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
25
02
2022
accepted:
15
04
2022
pubmed:
7
5
2022
medline:
20
7
2022
entrez:
6
5
2022
Statut:
ppublish
Résumé
Our aim was to compare cerebrovascular and systemic vascular function between older adults with and without mild cognitive impairment (MCI), and to determine which measures of vascular function best predict the presence of MCI. In 41 adults with MCI and 33 adults without MCI (control) we compared middle cerebral artery velocity (MCAv) and cerebrovascular pulsatility index (PI) at rest, cerebrovascular reactivity to CO Cerebrovascular PI was higher in MCI compared with control (mean ± SD: 1.17 ± 0.27 vs. 1.04 ± 0.21), and MCI exhibited a lower %∆MCAv/%∆MAP (1.26 ± 0.44 vs. 1.50 ± 0.55%). Absolute (p = 0.76) and relative cerebrovascular reactivity to CO These findings raise the possibility that early changes in systemic vascular stiffness and endothelial function may contribute to altered cerebrovascular haemodynamics and impaired cognitive function, and present potential targets for prevention and treatment strategies in people with MCI.
Identifiants
pubmed: 35522276
doi: 10.1007/s00421-022-04956-w
pii: 10.1007/s00421-022-04956-w
pmc: PMC9287231
doi:
Substances chimiques
Carbon Dioxide
142M471B3J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1843-1856Informations de copyright
© 2022. The Author(s).
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