Overabundance of Veillonella parvula promotes intestinal inflammation by activating macrophages via LPS-TLR4 pathway.
Journal
Cell death discovery
ISSN: 2058-7716
Titre abrégé: Cell Death Discov
Pays: United States
ID NLM: 101665035
Informations de publication
Date de publication:
06 May 2022
06 May 2022
Historique:
received:
29
07
2021
accepted:
24
09
2021
revised:
13
09
2021
entrez:
6
5
2022
pubmed:
7
5
2022
medline:
7
5
2022
Statut:
epublish
Résumé
Hirschsprung's disease-associated enterocolitis (HAEC) is the most common complication of Hirschsprung's disease (HSCR). The microbiome pattern of intestinal flora in HAEC patients was significantly abnormal compared to that in HSCR patients. The overabundance of V. parvula was detected in the gut of HAEC patients. To elucidate the pathological mechanisms of the overabundance of V. parvula, we established and analyzed inflammatory models induced by LPS or single-bacterial strain transplantation in vivo. The transplantation of V. parvula induced inflammatory response in the colon of mice. Besides, we found that LPS from V. parvula can significantly impair the barrier function of colonic epithelial cells and then activate macrophages which impaired pacemaker function of interstitial cells of Cajal (ICCs). It was thus a vicious cycle, where the macrophage-related inflammation caused by V. parvula via LPS-TLR4 pathway damaged the intestinal motility, which further aggravated the intestinal flora dysbiosis and promoted the development of HAEC. Itaconic acid could break the vicious cycle by inhibiting the activation of macrophages. It could be a potential therapeutic strategy for HAEC patients with intestinal flora dysbiosis.
Identifiants
pubmed: 35523778
doi: 10.1038/s41420-022-01015-3
pii: 10.1038/s41420-022-01015-3
pmc: PMC9076897
doi:
Types de publication
Journal Article
Langues
eng
Pagination
251Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81771630
Informations de copyright
© 2022. The Author(s).
Références
Innate Immun. 2011 Feb;17(3):269-82
pubmed: 20472611
Nat Rev Immunol. 2001 Nov;1(2):135-45
pubmed: 11905821
Immunol Rev. 2014 Nov;262(1):153-66
pubmed: 25319333
Nat Rev Microbiol. 2019 Jul;17(7):403-416
pubmed: 31142822
J Clin Microbiol. 1996 May;34(5):1283-5
pubmed: 8727920
Biomed Pharmacother. 2018 Aug;104:622-628
pubmed: 29803175
Theranostics. 2021 Apr 15;11(13):6278-6292
pubmed: 33995658
PLoS One. 2010 Jan 13;5(1):e8668
pubmed: 20084270
J Exp Med. 2020 Feb 13;217(3):e20192195
pubmed: 32997932
PLoS One. 2016 Sep 07;11(9):e0162079
pubmed: 27603009
Redox Biol. 2013 Jan 18;1:45-9
pubmed: 24024136
Emerg Infect Dis. 2005 Jul;11(7):1112-4
pubmed: 16022792
Signal Transduct Target Ther. 2021 Mar 31;6(1):129
pubmed: 33785736
Front Immunol. 2021 Feb 05;11:598152
pubmed: 33613519
Semin Pediatr Surg. 2012 Nov;21(4):328-35
pubmed: 22985838
Gut Microbes. 2020 Jul 3;11(4):842-854
pubmed: 31944159
Biomed Pharmacother. 2019 Sep;117:109138
pubmed: 31247468
Methods Mol Biol. 2019;1960:101-112
pubmed: 30798525
Pediatr Surg Int. 2013 Sep;29(9):873-81
pubmed: 23913261
Nature. 2018 Apr 5;556(7699):113-117
pubmed: 29590092
Cell Death Dis. 2019 Mar 20;10(4):271
pubmed: 30894510
Front Microbiol. 2015 Oct 16;6:1154
pubmed: 26528281
J Clin Invest. 2020 Dec 1;130(12):6443-6456
pubmed: 32809970
Int J Mol Sci. 2020 Jun 25;21(12):
pubmed: 32630607
J Pediatr Surg. 2016 Jan;51(1):18-22
pubmed: 26611330
Chin Med J (Engl). 2016 Jun 20;129(12):1491-7
pubmed: 27270548
Biochem Biophys Res Commun. 2014 Mar 7;445(2):269-74
pubmed: 24525127
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7820-5
pubmed: 23610393
PeerJ. 2019 Jul 22;7:e7310
pubmed: 31367483
Cell. 2017 Feb 23;168(5):928-943.e11
pubmed: 28215708
J Am Chem Soc. 2011 Oct 19;133(41):16386-9
pubmed: 21919507
Annu Rev Physiol. 2017 Feb 10;79:567-592
pubmed: 27959619
Gastroenterology. 2014 Mar;146(3):765-75
pubmed: 24269927
Cell. 2011 Nov 11;147(4):868-80
pubmed: 22078883
Neurogastroenterol Motil. 2012 Jun;24(6):503-12
pubmed: 22583600
Science. 2018 Nov 30;362(6418):
pubmed: 30498100
N Engl J Med. 2016 Dec 15;375(24):2369-2379
pubmed: 27974040