The interaction between endogenous GABA, functional connectivity, and behavioral flexibility is critically altered with advanced age.

Adult Humans Longitudinal Studies Motor Cortex / physiology gamma-Aminobutyric Acid

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
06 05 2022
Historique:
received: 21 03 2021
accepted: 19 04 2022
entrez: 6 5 2022
pubmed: 7 5 2022
medline: 11 5 2022
Statut: epublish

Résumé

The flexible adjustment of ongoing behavior challenges the nervous system's dynamic control mechanisms and has shown to be specifically susceptible to age-related decline. Previous work links endogenous gamma-aminobutyric acid (GABA) with behavioral efficiency across perceptual and cognitive domains, with potentially the strongest impact on those behaviors that require a high level of dynamic control. Our analysis integrated behavior and modulation of interhemispheric phase-based connectivity during dynamic motor-state transitions with endogenous GABA concentration in adult human volunteers. We provide converging evidence for age-related differences in the preferred state of endogenous GABA concentration for more flexible behavior. We suggest that the increased interhemispheric connectivity observed in the older participants represents a compensatory neural mechanism caused by phase-entrainment in homotopic motor cortices. This mechanism appears to be most relevant in the presence of a less optimal tuning of the inhibitory tone as observed during healthy aging to uphold the required flexibility of behavioral action. Future work needs to validate the relevance of this interplay between neural connectivity and GABAergic inhibition for other domains of flexible human behavior.

Identifiants

DOI: 10.1038/s42003-022-03378-w PMID: 35523951 PMC: PMC9076638
pubmed: 35523951
doi: 10.1038/s42003-022-03378-w
pii: 10.1038/s42003-022-03378-w
pmc: PMC9076638
doi:

Substances chimiques

gamma-Aminobutyric Acid 56-12-2

Banques de données

figshare
['10.6084/m9.figshare.14256314']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

426

Informations de copyright

© 2022. The Author(s).

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Auteurs

Kirstin-Friederike Heise (KF)

Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, Leuven, Belgium. kirstin.heise@kuleuven.be.
KU Leuven Brain Institute, Leuven, Belgium. kirstin.heise@kuleuven.be.
ORCID: 0000-0003-3666-8531

Laura Rueda-Delgado (L)

Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, Leuven, Belgium.
School of Psychology, Trinity College Dublin, Dublin, 2, Ireland.

Sima Chalavi (S)

Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, Leuven, Belgium.
KU Leuven Brain Institute, Leuven, Belgium.

Bradley R King (BR)

Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, Leuven, Belgium.
KU Leuven Brain Institute, Leuven, Belgium.
Department of Health & Kinesiology, College of Health, University of Utah, Salt Lake City, UT, USA.

Thiago Santos Monteiro (TS)

Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, Leuven, Belgium.
KU Leuven Brain Institute, Leuven, Belgium.

Richard A E Edden (RAE)

The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.

Dante Mantini (D)

Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, Leuven, Belgium.
Brain Imaging and Neural Dynamics Research Group, IRCCS San Camillo Hospital, Venice, Italy.
ORCID: 0000-0001-6485-5559

Stephan P Swinnen (SP)

Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, Leuven, Belgium.
KU Leuven Brain Institute, Leuven, Belgium.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The interaction between endogenous GABA,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The interaction between endogenous GABA,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › The interaction between endogenous GABA,...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Cortex sensorimoteur › Cortex moteur › The interaction between endogenous GABA,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › The interaction between endogenous GABA,...