Oral lichen planus: comparative efficacy and treatment costs-a systematic review.
Administration, Topical
Calcineurin Inhibitors
/ therapeutic use
Clobetasol
/ therapeutic use
Cyclosporins
/ therapeutic use
Dexamethasone
/ therapeutic use
Fluocinonide
/ therapeutic use
Health Care Costs
Humans
Lichen Planus, Oral
/ drug therapy
Steroids
/ therapeutic use
Tacrolimus
/ therapeutic use
Treatment Outcome
Triamcinolone
/ therapeutic use
Cost
Critical review
Efficacy
Oral lichen planus
Treatment
Journal
BMC oral health
ISSN: 1472-6831
Titre abrégé: BMC Oral Health
Pays: England
ID NLM: 101088684
Informations de publication
Date de publication:
06 05 2022
06 05 2022
Historique:
received:
04
01
2022
accepted:
11
04
2022
entrez:
7
5
2022
pubmed:
8
5
2022
medline:
11
5
2022
Statut:
epublish
Résumé
To compare the reported efficacy and costs of available interventions used for the management of oral lichen planus (OLP). A systematic literature search was performed from database inception until March 2021 in MEDLINE via PubMed and the Cochrane library following PRISMA guidelines. Only randomized controlled trials (RCT) comparing an active intervention with placebo or different active interventions for OLP management were considered. Seventy (70) RCTs were included. The majority of evidence suggested efficacy of topical steroids (dexamethasone, clobetasol, fluocinonide, triamcinolone), topical calcineurin inhibitors (tacrolimus, pimecrolimus, cyclosporine), topical retinoids, intra-lesional triamcinolone, aloe-vera gel, photodynamic therapy, and low-level laser therapies for OLP management. Based on the estimated cost per month and evidence for efficacy and side-effects, topical steroids (fluocinonide > dexamethasone > clobetasol > triamcinolone) appear to be more cost-effective than topical calcineurin inhibitors (tacrolimus > pimecrolimus > cyclosporine) followed by intra-lesional triamcinolone. Of common treatment regimens for OLP, topical steroids appear to be the most economical and efficacious option followed by topical calcineurin inhibitors. Large-scale multi-modality, prospective trials in which head-to-head comparisons interventions are compared are required to definitely assess the cost-effectiveness of OLP treatments.
Identifiants
pubmed: 35524296
doi: 10.1186/s12903-022-02168-4
pii: 10.1186/s12903-022-02168-4
pmc: PMC9074269
doi:
Substances chimiques
Calcineurin Inhibitors
0
Cyclosporins
0
Steroids
0
Triamcinolone
1ZK20VI6TY
Fluocinonide
2W4A77YPAN
Dexamethasone
7S5I7G3JQL
Clobetasol
ADN79D536H
Tacrolimus
WM0HAQ4WNM
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
161Informations de copyright
© 2022. The Author(s).
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