Endoplasmic reticulum stress in liver diseases.
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
01 02 2023
01 02 2023
Historique:
received:
02
11
2021
accepted:
08
03
2022
pmc-release:
01
02
2024
pubmed:
8
5
2022
medline:
28
1
2023
entrez:
7
5
2022
Statut:
ppublish
Résumé
The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding of linear polypeptides and proteins, a process tightly governed by the ER-resident enzymes and chaperones. Failure to shape the proper 3-dimensional architecture of proteins culminates in the accumulation of misfolded or unfolded proteins within the ER, disturbs ER homeostasis, and leads to canonically defined ER stress. Recent studies have elucidated that cellular perturbations, such as lipotoxicity, can also lead to ER stress. In response to ER stress, the unfolded protein response (UPR) is activated to reestablish ER homeostasis ("adaptive UPR"), or, conversely, to provoke cell death when ER stress is overwhelmed and sustained ("maladaptive UPR"). It is well documented that ER stress contributes to the onset and progression of multiple hepatic pathologies including NAFLD, alcohol-associated liver disease, viral hepatitis, liver ischemia, drug toxicity, and liver cancers. Here, we review key studies dealing with the emerging role of ER stress and the UPR in the pathophysiology of liver diseases from cellular, murine, and human models. Specifically, we will summarize current available knowledge on pharmacological and non-pharmacological interventions that may be used to target maladaptive UPR for the treatment of nonmalignant liver diseases.
Identifiants
pubmed: 35524448
pii: 01515467-202302000-00027
doi: 10.1002/hep.32562
pmc: PMC9637239
mid: NIHMS1805030
doi:
Substances chimiques
Molecular Chaperones
0
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
619-639Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL160472
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK111378
Pays : United States
Informations de copyright
Copyright © 2023 American Association for the Study of Liver Diseases.
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