Findings, limitations and new directions in tACS studies in schizophrenia research: A scoping review.
Schizophrenia” and “transcranial alternating current stimulation”
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
23
08
2021
revised:
13
04
2022
accepted:
25
04
2022
pubmed:
8
5
2022
medline:
18
6
2022
entrez:
7
5
2022
Statut:
ppublish
Résumé
Schizophrenia (SZ) is a severe neurodevelopmental spectrum disorder with significant consequences for the individual who is diagnosed and their family, resulting in notable system-level costs associated with the current methods of treatment. With a complex etiology, this syndrome continues to evade our thorough understanding and invites cautious analysis into how the newest research findings may translate into meaningful interventions. Recent explorations of non-invasive interventions in psychiatry suggest that transcranial alternating current stimulation (tACS) is a safe and potentially promising add-on to the current SZ treatment. We performed a systematic literature search for tACS studies on SZ in three databases - Embase, Pubmed and Medline. The search yielded 29 titles and abstracts, of which 8 met the criteria for inclusion: experimental use of tACS on patients with SZ. We found 8 publications where findings from tACS were applied on participants with SZ. The most common frequencies used were theta (4.5 Hertz [Hz] and 6 Hz), alpha (10 Hz) and gamma (40 Hz). The main findings resulting from tACS delivery were: (1) decrease in auditory hallucinations; (2) decrease in negative symptoms; (3) cognitive improvement; and, (4) no change. This scoping review provides a highlight of current protocols used in tACS studies on SZ, their main findings and limitations, and points towards a direction for new approaches. The wide variety of objectives, protocols and assessments used by researchers demonstrates the diversified nature of research currently used in this field, suggesting the need for a more thorough exploration as results continue to emerge.
Sections du résumé
BACKGROUND
Schizophrenia (SZ) is a severe neurodevelopmental spectrum disorder with significant consequences for the individual who is diagnosed and their family, resulting in notable system-level costs associated with the current methods of treatment. With a complex etiology, this syndrome continues to evade our thorough understanding and invites cautious analysis into how the newest research findings may translate into meaningful interventions. Recent explorations of non-invasive interventions in psychiatry suggest that transcranial alternating current stimulation (tACS) is a safe and potentially promising add-on to the current SZ treatment.
METHODS
We performed a systematic literature search for tACS studies on SZ in three databases - Embase, Pubmed and Medline. The search yielded 29 titles and abstracts, of which 8 met the criteria for inclusion: experimental use of tACS on patients with SZ.
RESULTS
We found 8 publications where findings from tACS were applied on participants with SZ. The most common frequencies used were theta (4.5 Hertz [Hz] and 6 Hz), alpha (10 Hz) and gamma (40 Hz). The main findings resulting from tACS delivery were: (1) decrease in auditory hallucinations; (2) decrease in negative symptoms; (3) cognitive improvement; and, (4) no change.
CONCLUSIONS
This scoping review provides a highlight of current protocols used in tACS studies on SZ, their main findings and limitations, and points towards a direction for new approaches. The wide variety of objectives, protocols and assessments used by researchers demonstrates the diversified nature of research currently used in this field, suggesting the need for a more thorough exploration as results continue to emerge.
Identifiants
pubmed: 35525231
pii: S0022-3956(22)00237-0
doi: 10.1016/j.jpsychires.2022.04.036
pii:
doi:
Types de publication
Journal Article
Review
Systematic Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
291-298Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.