Skeletal muscle gene expression in older adults with type 2 diabetes mellitus undergoing calorie-restricted diet and recreational sports training - a randomized clinical trial.
Aged
Caloric Restriction
Diabetes Mellitus, Type 2
/ genetics
Exercise
/ physiology
Gene Expression
Humans
Interleukin-15
/ biosynthesis
Muscle Proteins
/ biosynthesis
Muscle, Skeletal
/ metabolism
RNA, Messenger
/ genetics
SKP Cullin F-Box Protein Ligases
/ biosynthesis
Tripartite Motif Proteins
/ biosynthesis
Ubiquitin-Protein Ligases
/ biosynthesis
Exercise
Interleukin-15
Muscle proteins
Nutritional intervention
Overweight
Ubiquitin-protein ligases
Journal
Experimental gerontology
ISSN: 1873-6815
Titre abrégé: Exp Gerontol
Pays: England
ID NLM: 0047061
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
03
12
2021
revised:
10
02
2022
accepted:
02
05
2022
pubmed:
8
5
2022
medline:
3
6
2022
entrez:
7
5
2022
Statut:
ppublish
Résumé
This study aimed to evaluate the impact of a 12-week calorie-restricted diet and recreational sports training on gene expressions IL-15, ATROGIN-1 and MURF-1 in skeletal muscle of T2D patients. Older adults with T2D (n = 39, 60 ± 6.0 years, BMI 33.5 ± 0.6 kg/m Total body weight was reduced in ~4 kg representing body fat mass in all groups after 12-weeks (P < 0.05). HbA1c values decreased in all groups post-intervention. Lipids profile improved in the training groups (P < 0.05) after 12-weeks. ATROGIN-1 and MURF-1 mRNA reduced in the DS (1.084 ± 0.14 vs. 0.754 ± 1.14 and 1.175 ± 0.34 vs. 0.693 ± 0.12, respectively; P < 0.05), while IL-15 mRNA increased in the DR (1.056 ± 0.12 vs. 1.308 ± 0.13; P < 0.05) after 12-weeks intervention. Recreational training with a moderate calorie-restricted diet can downregulates the expression of atrophy-associated myokines and increases the expression of anti-inflammatory gene IL-15.
Identifiants
pubmed: 35525396
pii: S0531-5565(22)00139-5
doi: 10.1016/j.exger.2022.111831
pii:
doi:
Substances chimiques
IL15 protein, human
0
Interleukin-15
0
Muscle Proteins
0
RNA, Messenger
0
Tripartite Motif Proteins
0
FBXO32 protein, human
EC 2.3.2.27
SKP Cullin F-Box Protein Ligases
EC 2.3.2.27
TRIM63 protein, human
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111831Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.