Imbalance of circulating innate lymphoid cell subpopulations in patients with chronic kidney disease.

Humans Immunity, Innate Lymphocytes Renal Insufficiency, Chronic / metabolism
Chronic kidney disease Diabetic nephropathy Innate immunity Innate lymphoid cells Lupus nephritis

Journal

Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537

Informations de publication

Date de publication:
06 2022
Historique:
received: 22 07 2021
revised: 27 04 2022
accepted: 29 04 2022
pubmed: 8 5 2022
medline: 3 6 2022
entrez: 7 5 2022
Statut: ppublish

Résumé

Innate lymphoid cells (ILCs) are a newly identified heterogeneous family of innate immune cells. We conducted this study to investigate the frequency of circulating ILC subsets in various chronic kidney diseases (CKD). In DN, the proportion of total ILCs and certain ILC subgroups increased significantly. Positive correlations between proportion of total ILCs, ILC1s and body mass index, glycated hemoglobin were observed in DN. In LN, a significantly increased proportion of ILC1s was found in parallel with a reduced proportion of ILC2s. The proportions of total ILCs and ILC1s were correlated with WBC count and the level of C3. In all enrolled patients, the proportion of total ILCs and ILC1s was significantly correlated with the levels of ACR and GFR. In the present study, the proportion of circulating ILC subsets increased significantly in various types of CKD and correlated with clinico-pathological features, which suggests a possible role for ILCs in CKD.

Identifiants

DOI: 10.1016/j.clim.2022.109029 PMID: 35525476
pubmed: 35525476
pii: S1521-6616(22)00110-3
doi: 10.1016/j.clim.2022.109029
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109029

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Ruifeng Wang (R)

Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China; Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia; Department of Nephrology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Jingjing Zhang (J)

Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Dandan Li (D)

Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Guiling Liu (G)

Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Yuqin Fu (Y)

Department of Nephrology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Qing Li (Q)

The Central Laboratory of Medical Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Lei Zhang (L)

Department of Rheumatology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Long Qian (L)

Department of Rheumatology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Li Hao (L)

Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Yiping Wang (Y)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.

David C H Harris (DCH)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.

Deguang Wang (D)

Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. Electronic address: wangdeguang@ahmu.edu.cn.

Qi Cao (Q)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia. Electronic address: qi.cao@sydney.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Imbalance of circulating innate lymphoid cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Imbalance of circulating innate lymphoid cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Imbalance of circulating innate lymphoid cell...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Imbalance of circulating innate lymphoid cell...